Functional evidence for subsensitivity of noradrenergic alpha 2 receptors after chronic desipramine treatment.
Functional evidence for subsensitivity of noradrenergic alpha 2 receptors after chronic desipramine treatment.
复制标题
长期地昔帕明治疗后去甲肾上腺素能α2受体不敏感的功能证据。
DOI：
10.1016/0024-3205(80)90431-2
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发表时间：
1980
期刊：
影响因子：
6.1
通讯作者：
H. Fibiger
中科院分区：
文献类型：
--
作者：
C. Spyraki;H. Fibiger
在大鼠中研究了地昔帕明（地昔帕明）急性（2天）和慢性（15天）给药对可乐定诱导的探索行为抑制的影响。与之前的结果一致，低剂量（25-100 μg/kg）可乐定导致对照动物的探索活动呈剂量依赖性降低。可乐定的这种作用在慢性阻塞性肺疾病组中明显减弱。急性期用地塞米松治疗无效。这些结果为最近的生物化学和神经生理学数据提供了行为支持，这些数据表明，慢性给药导致中枢去甲肾上腺素能神经元突触前受体的亚敏感性。
The effects of acute (2 day) and chronic (15 day) administration of desipramine (DMI) on clonidine-induced suppression of exploratory behavior was investigated in the rat. In accordance with previous results, low doses (25–100 μg/kg) of clonidine produced a dose-dependent decrease in explaratory activity in control animals. This effect of clonidine was markedly attenuated in the chronic DMI groups. Acute treatment with DMI was without effect. The results provide behavioral support for recent biochemical and neurophysiological data which have suggested that chronic DMI administration results in subsensitivity of presynaptic receptors on central noradrenergic neurons.