Interleukin-1B (IL-1B) polymorphisms and gastric mucosal levels of IL-1β cytokine in Korean patients with gastric cancer
Interleukin-1B (IL-1B) polymorphisms and gastric mucosal levels of IL-1β cytokine in Korean patients with gastric cancer
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DOI：
10.1002/ijc.20724
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发表时间：
2005-04-10
影响因子：
6.4
通讯作者：
Chang, R
中科院分区：
文献类型：
--
作者：
Chang, YW;Jang, JY;Chang, R
白细胞介素-1B和白细胞介素-1受体拮抗剂基因多态性与高加索人群胃癌（GC）风险增加相关然而，最近的研究没有发现IL-1B-511 T多态性与亚洲人GC风险之间的任何关联。我们在韩国人群中检测了IL-1基因座多态性与胃粘膜IL-1 β水平升高和GC发生风险增加之间的相关性。对434例正常人和234例胃癌患者进行IL-1A-889、IL-1B-31、IL-1B-511和IL-1 RN基因多态性分析。使用ELISA测量粘蛋白IL-10细胞因子。IL-1A、IL-1B-511、IL-1B-31和IL-1 RN的频率在对照组和所有GC患者之间无统计学差异。GC亚类分类后，IL-1B-31 T纯合子的发生率仅为胆囊型（OR = 2.2，95%CI = 1.1-4.3）。与弥漫型GC患者相比，IL-1B-31 T纯合子患者的风险也显著增加（OR = 3.4; 95% CI = 1.5-7.7）。在高加索人群中，IL-1B-31和IL-1B-511之间的连锁不平衡几乎是完全的，但与GC风险相关的单倍型模式（IL-1B-31 T/IL-1B-511 C）是相反的（IL-1B-511 T/IL-1B-31 C）。H.与IL-1B-31 C/T和IL-1B-31 C/C相比，IL-1B-31 T纯合子患者中幽门螺杆菌感染的GC患者更高。因此，H. pylori感染和IL-1B-31 T/IL-1B-511 C多态性以及粘膜IL-1 β产生增加促进了该韩国人群中胃肠道型GC的发展。(C)2004 Wiley-Liss，Inc.
Interleukin-1B and IL-1 receptor antagonist gene polymorphisms are associated with an increased risk of gastric cancer (GC) in Caucasian populations. However, recent studies could not find any association between IL-1B-511T polymorphism and the risk of GC in Asians. We tested for an association between IL-1 loci polymorphisms with increased gastric mucosal levels of IL-1beta and an increased risk of developing GC in a Korean population. Polymorphisms of IL-1A-889, IL-1B-31, IL-1B-511 and IL-1RN were genotyped in 434 controls and 234 patients with GC. Mucosal IL-10 cytokine was measured using an ELISA. The frequencies of IL-1A, IL-1B-511, IL-1B-31 and IL-1RN were not statistically different between controls and all patients with GC. After subclassification of GC, only patients with intestinal-type GC showed a higher frequency of IL-1B-31T homozygotes (OR = 2.2; 95% CI = 1.1-4.3) compared with controls. Risk was also significantly increased in these patients for IL-1B-31T homozygotes compared with patients with diffuse-type GC (OR = 3.4; 95% CI = 1.5-7.7). As in Caucasian populations, linkage disequilibrium between IL-1B-31 and IL-1B-511 was nearly complete, but the pattern of haplotype related to the risk of GC (IL-1B-31T/IL-1B-511C) was opposite (IL-1B-511T/IL-1B-31C). Mucosal IL-1beta levels in H. pylori-infected GC patients were higher in patients homozygous for IL-1B-31T compared with IL-1B-31C/T and IL-1B-31C/C. Thus, the combined effects of H. pylori infection and IL-1B-31T/IL-1B-511C polymorphisms with enhanced mucosal IL-1beta production contributed to the development of intestinal-type GC in this Korean population. (C) 2004 Wiley-Liss, Inc.