Dynamic changes in sensitization to specific aeroallergens in children raised in a desert environment
Dynamic changes in sensitization to specific aeroallergens in children raised in a desert environment
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DOI：
10.1111/j.1365-2222.2004.02088.x
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发表时间：
2004-10-01
影响因子：
6.1
通讯作者：
Halonen, M
中科院分区：
文献类型：
--
作者：
Stern, DA;Lohman, IC;Halonen, M
背景过敏原皮肤试验反应性和血清总IgE是用于表征和帮助诊断过敏性疾病的客观指标。横断面研究表明，在整个儿童期，空气过敏原皮肤试验的反应性总体上会增加。然而，很少有人注意到是否发生了个体吸入性变应原汇款，目的了解6-11岁儿童过敏原皮试反应的发生率和转归。方法对828名6-11岁儿童进行6种变应原的纵向致敏性和总IgE的测定。结果6 ~ 11岁儿童新发致敏率为30.2%，6岁以前为39.7%。6 ~ 11岁儿童从阳性到阴性的完全缓解率为8.2%，6岁时的总IgE无预测性。个别过敏原的缓解率很高，且变化不定（19-49%）。常年过敏原百慕大和链格孢属是早期致敏物，汇款率低。早期致敏的四个季节性过敏原是不太常见的，更容易汇款与大部分的致敏发生在6和11 years.Conclusion本研究表明，在儿童时期的个别空气过敏原的致敏是动态的，并表明皮肤试验反应性的单点评估的局限性。
Background Allergen skin test reactivity and total serum IgE are objective measures used to characterize and help diagnose allergic diseases. Cross-sectional studies have shown that overall aeroallergen skin test reactivity increases throughout childhood. However, little attention has been paid to whether individual aeroallergen remittance occurs, which could distort or mask relationships to disease.Objective To access the incidence and remittance of skin test reactions to individual allergens in children aged 6-11 years.Methods Longitudinal sensitization to six aeroallergens and total IgE were assessed in 828 children raised in the semi-arid US southwest at ages 6 and 11 years.Results New sensitization (to any allergen) between 6 and 11 years occurred in 30.2% of children compared with 39.7% before age 6 years. The rate of complete remittance from positive to negative between ages 6 and 11 years was 8.2%, and total IgE at age 6 years was not predictive. Remittance rates for individual allergens were high and variable (19-49%). The perennial allergens Bermuda and Alternaria were early sensitizers and had low remittance rates. Early sensitization to the four seasonal allergens was less common and more subject to remittance with the bulk of sensitization occurring between 6 and 11 years.Conclusion This study shows that sensitization to individual aeroallergens in childhood is dynamic and indicates the limitation of single point assessment of skin test reactivity.