Characterization of the Immune Cell Infiltration Landscape in Head and Neck Squamous Cell Carcinoma to Aid Immunotherapy.
Characterization of the Immune Cell Infiltration Landscape in Head and Neck Squamous Cell Carcinoma to Aid Immunotherapy.
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DOI：
10.1016/j.omtn.2020.08.030
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发表时间：
2020-12-04
期刊：
影响因子：
--
通讯作者：
Zhang B
中科院分区：
文献类型：
--
作者：
Zhang X;Shi M;Chen T;Zhang B
肿瘤微环境(TME)主要由肿瘤细胞和肿瘤浸润性免疫细胞混合基质成分组成。最近的一项临床试验表明，肿瘤免疫细胞浸润(ICI)与免疫治疗的敏感性和头颈部鳞状细胞癌(HNSC)的预后有关。然而，到目前为止，hNSC的免疫浸润性情况还没有被阐明。在这里，我们提出了两种计算算法来揭示1,029名hNSC患者的ICI情况。定义了三种ICI模式，并通过主成分分析确定了ICI评分。高ICI评分的特征是肿瘤突变负荷(TMB)和免疫激活信号通路增加。转化生长因子-β(转化生长因子-β)和WNT信号通路在低ICI亚型中被激活，提示T细胞抑制，可能与预后不良有关。ICI评分较高的两个免疫治疗队列确诊患者显示出显著的治疗优势和临床益处。本研究表明，ICI评分可作为免疫治疗的有效预后生物标志物和预测指标。评估更大样本的ICI模式将扩大我们对TME的理解，并可能为目前针对hNSC的免疫治疗策略的研究提供方向。了解肿瘤免疫微环境对于提高当前免疫疗法的疗效至关重要。张等人。综合评估与免疫细胞渗透模式相关的细胞、分子和遗传因素。这些对于肿瘤对免疫治疗的反应具有重要的意义，并可能指导更有效的免疫治疗策略。
The tumor microenvironment (TME) chiefly consists of tumor cells and tumor-infiltrating immune cells admixed with the stromal component. A recent clinical trial has shown that the tumor immune cell infiltration (ICI) is correlated with the sensitivity to immunotherapy and the head and neck squamous cell carcinoma (HNSC) prognosis. However, to date, the immune infiltrative landscape of HNSC has not yet been elucidated. Herein, we proposed two computational algorithms to unravel the ICI landscape of 1,029 HNSC patients. Three ICI patterns were defined, and the ICI scores were determined by using principal-component analysis. A high ICI score was characterized by an increased tumor mutation burden (TMB) and the immune-activating signaling pathways. Activation of transforming growth factor-β (TGF-β) and WNT signaling pathways were observed in low ICI score subtypes, indicating T cell suppression, and may be responsible for poor prognosis. Two immunotherapy cohorts confirmed patients with higher ICI scores demonstrated significant therapeutic advantages and clinical benefits. This study demonstrated that the ICI scores serve as an effective prognostic biomarker and predictive indicator for immunotherapy. Evaluating the ICI patterns of a larger cohort of samples will extend our understanding of TME, and it may provide directions to the current research investigations on immunotherapeutic strategies for HNSC. Understanding the tumor-immune microenvironment is critical for improving the efficacy of current immunotherapies. Zhang et al. comprehensively evaluated the cellular, molecular, and genetic factors associated with immune cell infiltration patterns. These have important implications for how tumors respond to immunotherapies and may guide more effective immunotherapy strategies.
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影响因子：
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作者：
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DOI：
10.1126/science.aar3593
发表时间：
2018-10-12
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
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通讯作者：
Kaufman D