Conformation and dynamics of single DNA molecules in parallel-plate slit microchannels
Conformation and dynamics of single DNA molecules in parallel-plate slit microchannels
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DOI：
10.1103/physreve.70.060901
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发表时间：
2004-12-01
影响因子：
2.4
通讯作者：
Doyle, PS
中科院分区：
文献类型：
--
作者：
Chen, YL;Graham, MD;Doyle, PS
限制在两个平行板之间的单个DNA分子的构象和扩散研究使用单分子实验和布朗动力学模拟占流体动力学相互作用。链拉伸和扩散的程度的特征在于作为链限制和通道几何形状的函数。良好的协议之间的模拟，实验和标度理论的预测。
The conformation and diffusion of a single DNA molecule confined between two parallel plates are examined using both single molecule experiments and Brownian dynamics simulations accounting for hydrodynamic interactions. The degree of chain stretching and the diffusivity are characterized as a function of the chain confinement and the channel geometry. Good agreement is found between the simulations, experiments, and scaling theory predictions.