Functional MRI of arousals in nonrapid eye movement sleep
Functional MRI of arousals in nonrapid eye movement sleep
复制标题
非快速眼动睡眠中唤醒的功能 MRI
作者：
Zou Guangyuan;Xu Jing;Zhou Shuqin;Liu Jiayi;Su Zi Hui;Zou Qihong;Gao Jia-Hong
觉醒通常发生在人类睡眠中，并与几种睡眠障碍有关。觉醒的特征是在睡眠期间突然的脑电图（EEG）频率变化到更高的频率。然而，人类大脑中与觉醒有关的区域尚不清楚。同时记录了健康年轻人在睡眠初期的脑电图和功能磁共振成像（fMRI）数据。基于脑电数据识别醒觉，分析19例受试者83次醒觉的fMRI信号变化。皮层下区域，包括中脑、丘脑、基底神经节和小脑，被唤醒激活。大脑皮层，包括颞回、枕回和额回，随着觉醒而失活。在皮层下区域与觉醒相关的激活与先前的皮层下参与行为唤醒和意识的发现是一致的。皮层失活可能作为一种机制，将传入的感觉刺激引导到特定的大脑区域，从而监测睡眠期间的环境扰动。
Arousals commonly occur during human sleep and have been associated with several sleep disorders. Arousals are characterized as an abrupt electroencephalography (EEG) frequency change to higher frequencies during sleep. However, the human brain regions involved in arousal are not yet clear. Simultaneous EEG and functional magnetic resonance imaging (fMRI) data were recorded during the early portion of the sleep period in healthy young adults. Arousals were identified based on the EEG data, and fMRI signal changes associated with 83 arousals from 19 subjects were analyzed. Subcortical regions, including the midbrain, thalamus, basal ganglia, and cerebellum, were activated with arousal. Cortices, including the temporal gyrus, occipital gyrus, and frontal gyrus, were deactivated with arousal. The activations associated with arousal in the subcortical regions were consistent with previous findings of subcortical involvement in behavioral arousal and consciousness. Cortical deactivations may serve as a mechanism to direct incoming sensory stimuli to specific brain regions, thereby monitoring environmental perturbations during sleep.