The Effect of Variable Duration One Hertz Interference on Kindling
The Effect of Variable Duration One Hertz Interference on Kindling
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DOI：
10.1017/s0317167100023702
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发表时间：
1980-02
期刊：
影响因子：
--
通讯作者：
J. Gaito
中科院分区：
文献类型：
--
作者：
J. Gaito
摘要：本实验旨在评估不同持续时间的1 hz脑刺激对60 hz正弦波刺激引起的点火行为的影响。在两个实验中，诱发惊厥的有效阈值强度（ETI）是在四个不同的场合确定的，在确定之间穿插了5天的每日试验。每天，实验大鼠在第一次和第三次试验中用1赫兹电流刺激5、15、30、60、120、180或600秒，在第二次试验中用60赫兹电流刺激30秒。所有大鼠持续时间为15秒或更长，从ETI2到ETI4的60hz电流引起惊厥所需的强度稳定增加。仅60 hz正弦波刺激的大鼠和5秒组的大鼠，从ETI1到ETI4的值保持相对稳定，略有下降。在日常试验中，15秒组对惊厥行为的抑制是适度的，30秒组明显，其他组则是剧烈的。600第二组的操作抑制效果最大。抑制效果似乎不是由于组织损伤，因为大多数实验大鼠（除了600秒的那只）在实验结束后休息15或16天，在先前的低ETI水平上再次抽搐。这一结果表明，抑制效应是一个相对短暂的事件。
SUMMARY: Experiments were conducted to evaluate the effect of various durations of 1-Hz brain stimulation on kindling behaviour induced by 60-Hz sine wave stimulation. In two experiments the effective threshold intensity (ETI) to elicit a convulsion was determined on four separate occasions with 5 days of daily trials interspersed between determinations. On each day experimental rats were stimulated with I-Hz current on the first and third trials for 5, 15, 30, 60, 120, 180, or 600 seconds duration and with 60-Hz current for 30 seconds on the second trial. A steady increase in the intensity required to elicit a convulsion with 60-Hz current from ETI2 to ETI4 resulted for all rats with durations of 15 seconds or greater. Rats stimulated only with 60-Hz sine waves, and those in the 5 second group, maintained relatively stable values from ETI1 to ETI4 with a slight decline occurring. Suppression of convulsive behavior on daily trials was modest in the 15 second group, pronounced with the 30 second group, and drastic with the other groups. The 600 second group had the greatest suppressive effect operating. The suppression effect did not appear to be due to tissue damage inasmuch as most of the experimental rats (except the 600 seconds one) convulsed again at previous low ETI levels following a 15 or 16 day rest at the end of the experiment. This result suggests that the suppression effect is a relatively transient event.