Necrotizing arteritis and spinal subarachnoid hemorrhage in Sjögren syndrome
Necrotizing arteritis and spinal subarachnoid hemorrhage in Sjögren syndrome
复制标题
干燥综合征中的坏死性动脉炎和脊髓蛛网膜下腔出血
DOI：
10.1002/ana.410110614
复制
发表时间：
1982
影响因子：
11.2
通讯作者：
G. E. Alexander
中科院分区：
文献类型：
--
作者：
E. Alexander;C. Craft;C. Dorsch;R. Moser;T. Provost;G. E. Alexander
1例37岁原发性干燥综合征女性患者发生混合性冷球蛋白血症和系统性血管炎。坏死性脊髓前动脉炎导致蛛网膜下腔出血。虽然在混合型冷球蛋白血症中很少见，但最近在干燥综合征中发现了中枢神经系统并发症。患者血清中含有抗Ro（SSA）胞质抗原的抗体，这些抗体集中在cryocellulin组分中。抗Ro（SSA）抗体与干燥综合征患者血管炎的发生相关，这表明该患者的脊髓动脉炎和蛛网膜下腔出血可能与基础结缔组织疾病直接相关。
A 37‐year‐old woman with primary Sjögren syndrome developed mixed cryoglobulinemia and systemic vasculitis. Subarachnoid hemorrhage occurred as a result of necrotizing anterior spinal arteritis. Although rarely seen in mixed cryoglobulinemia, central nervous system complications have recently been documented in Sjögren syndrome. The patient's serum contained antibodies to the Ro(SSA) cytoplasmic antigen, and these antibodies were concentrated in the cryoglobulin fraction. Anti‐Ro(SSA) antibodies are associated with the occurrence of vasculitis in patients with Sjögren syndrome, which suggests that the spinal arteritis and subarachnoid hemorrhage in this patient may have been directly related to the underlying connective tissue disorder.