METHAMPHETAMINE-INDUCED BEHAVIORAL ALTERATIONS FOLLOWING REPEATED ADMINISTRATION OF METHAMPHETAMINE
METHAMPHETAMINE-INDUCED BEHAVIORAL ALTERATIONS FOLLOWING REPEATED ADMINISTRATION OF METHAMPHETAMINE
复制标题
DOI：
10.1254/jjp.41.147
复制
发表时间：
1986-06-01
期刊：
影响因子：
--
通讯作者：
EGASHIRA, T
中科院分区：
文献类型：
--
作者：
YAMANAKA, Y;TAKANO, R;EGASHIRA, T
大剂量甲基苯丙胺（MA） （25 mg/kg，每日两次，连续4天）反复给予小鼠运动活性增强，并在随后注射MA后减少刻板行为。同时测定的儿茶酚胺揭示了大脑多巴胺的消耗。中等剂量氟哌啶醇显著增强ma诱导小鼠的运动活性。6-羟多巴胺注入纹状体后，ma诱导的运动活动显著增强，且与纹状体多巴胺水平呈负相关。这些结果提示，反复给药导致纹状体多巴胺能神经元系统功能减退可能是由于刻板行为减少而导致的MA诱导的运动活动增强的机制之一。
Repeated administration of a large dose of methamphetamine (MA) (25 mg/kg, i.p. twice daily for 4 days) to mice enhanced locomotor activity and decreased stereotyped behaviour following a subsequent injection of MA. Simultaneous determinations of catecholamines revealed a depletion of brain dopamine. The moderate doses of haloperidol significantly enhanced MA-induced locomotor activity in mice. A significant enhancement of MA-induced locomotor activity was observed in the rats pretreated with 6-hydroxydopamine into the striatum, and this effect correlated negatively with the striatal dopamine level. These results suggest that hypofunction of striatal dopaminergic neuron systems induced by repeated administration of MA may be one of possible mechanisms of the enhancement of MA-induced locomotor activity due to the decrease of stereotyped behaviour.