Diet, genetics, and disease: a focus on the middle East and north Africa region.
Diet, genetics, and disease: a focus on the middle East and north Africa region.
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DOI：
10.1155/2012/109037
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发表时间：
2012
影响因子：
2.2
通讯作者：
Nemer GM
中科院分区：
文献类型：
--
作者：
Fahed AC;El-Hage-Sleiman AK;Farhat TI;Nemer GM
中东和北非（MENA）地区经历了从传统饮食到工业化饮食的巨大变化。这导致慢性病发病率空前增加。本文讨论了营养基因组学或饮食特征在中东和北非地区这些饮食和疾病变化中的作用。详细讨论了饮食-遗传-疾病的关系。在中东和北非地区选定的疾病类别进行了讨论，首先审查其流行病学在不同的中东和北非国家，然后通过检查已知的遗传因素，已报告的疾病讨论，无论是内部或外部的中东和北非地区。中东和北非地区的几种饮食-遗传学-疾病关系可能导致代谢紊乱和微量营养素缺乏症的流行率增加。未来需要在中东和北非营养基因组学领域进行研究，以更好地定义这些关系。
The Middle East and North Africa (MENA) region suffers a drastic change from a traditional diet to an industrialized diet. This has led to an unparalleled increase in the prevalence of chronic diseases. This review discusses the role of nutritional genomics, or the dietary signature, in these dietary and disease changes in the MENA. The diet-genetics-disease relation is discussed in detail. Selected disease categories in the MENA are discussed starting with a review of their epidemiology in the different MENA countries, followed by an examination of the known genetic factors that have been reported in the disease discussed, whether inside or outside the MENA. Several diet-genetics-disease relationships in the MENA may be contributing to the increased prevalence of civilization disorders of metabolism and micronutrient deficiencies. Future research in the field of nutritional genomics in the MENA is needed to better define these relationships.