STUDIES ON IMMUNOMODULATORY ACTIVITY of Aloe vera (Linn)
STUDIES ON IMMUNOMODULATORY ACTIVITY of Aloe vera (Linn)
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芦荟 (Linn) 免疫调节活性的研究
DOI：
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发表时间：
2011
期刊：
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通讯作者：
K. Kannan
中科院分区：
文献类型：
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作者：
A. Chandu;C. SanthoshKumar;C. Bhattacharjee;S. Debnath;K. Kannan
研究芦荟叶盐水提取物的免疫调节活性。 （科：百合科）白化小鼠。根据小鼠体重，口服芦荟叶的盐提取物。通过给予测试提取物来研究对特异性和非特异性免疫的免疫调节活性的评估。采用连苯三酚诱导的免疫抑制方法稍加修改来研究提取物的免疫调节潜力。通过血凝反应测量抗体滴度，进行对 SRBC 的体液抗体反应，并进行细胞免疫反应（足垫反应测试），通过在亚平面区域注射 SRBC（0.025x109 个细胞）在小鼠右爪中诱导水肿。每日口服芦荟盐水提取物可显着减弱连苯三酚诱导的体液和细胞介导的免疫反应抑制。维生素E治疗组表现出类似的免疫反应抑制减弱作用。研究发现，100 mg/kg 剂量的芦荟提取物可抑制小鼠 SRBC 诱导的迟发型超敏反应。正如还观察到小鼠血凝滴度显着增加所证明的那样。研究表明，维拉在更大程度上触发特异性和非特异性反应。该研究包括维拉的急性毒性和初步植物化学筛选。根据获得的结果和植物化学研究，芦荟的免疫刺激作用可归因于生物碱含量。关键词：免疫调节活性、芦荟、血液学、血清学研究。
To study the immunomodulatory activity of saline extracts of leaves of Aloe vera Linn. (Family: Liliaceae) on the albino mice. The saline extract of leaves of Aloe vera was administered orally according to their body weight in mice. The assessment of immunomodulatory activity on specific and nonspecific immunity was studied by administration of test extract. The method of pyrogallol induced immunosupression was employed with slight modification to study the immunomodulatory potential of the extract. Humoral antibody response to SRBC measurement of antibody titer by haemagglutination reaction was done and cellular immune response (Foot pad reaction test) the edema was induced in the right paw of mice by injecting SRBC (0.025x109 cells) in the sub planar region. Pyrogallol-induced suppression of humoral as well as cell mediated immune response was significantly attenuated by daily oral treatment with saline extract of Aloe vera. Vitamin E treated group exhibited similar attenuation of the suppression in immune responses. Aloe vera extract at the dose of 100 mg/kg was found to suppress delayed type hypersensitivity reaction induced by SRBCs in mice. As evidenced by marked increase in haemagglutination titers in mice was also observed. The study demonstrates that A. vera triggers both specific and non-specific responses to a greater extent. The study comprised the acute toxicity and preliminary phytochemical screening of A. vera. From the results obtained and phytochemical studies the immunostimulant effect of Aloe vera could be attributed to the alkaloids content. Keywords: Immunomodulatory activity, Aloe vera, Haematological, Serological studies.