The Joint Effect of Prenatal Exposure to Metal Mixtures on Neurodevelopmental Outcomes at 20-40 Months of Age: Evidence from Rural Bangladesh.
The Joint Effect of Prenatal Exposure to Metal Mixtures on Neurodevelopmental Outcomes at 20-40 Months of Age: Evidence from Rural Bangladesh.
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DOI：
10.1289/ehp614
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发表时间：
2017-06-26
影响因子：
10.4
通讯作者：
Wright RO
中科院分区：
文献类型：
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作者：
Valeri L;Mazumdar MM;Bobb JF;Claus Henn B;Rodrigues E;Sharif OIA;Kile ML;Quamruzzaman Q;Afroz S;Golam M;Amarasiriwardena C;Bellinger DC;Christiani DC;Coull BA;Wright RO
暴露在化学混合物中被认为是所有人口的现实情况，需要新的统计方法来评估其复杂的影响。我们的目标是评估宫内暴露于砷、锰和铅对儿童神经发育的联合影响。我们使用了一种新的统计方法，贝叶斯核机器回归(BKMR)，使用调整后的贝利婴幼儿发育™量表来研究砷、锰和铅共同暴露对神经发育的联合影响。第三版，从孟加拉国Pabna和Sirajdikhan地区的两个诊所招募的825对母婴进入预期出生队列。用电感耦合等离子体质谱检测脐带血中的金属元素。由于暴露情况的不同，分析按临床分层进行。在表现出高锰水平的帕布纳地区[四分位数范围(IQR)：4.8，]，我们发现当脐带血金属浓度均高于中位数(，，)时，砷、铅和锰的混合物对认知评分有统计学意义的负面影响。发现了锰的非线性效应的证据。当砷和锰处于中位数时，对数锰从第25个百分位数到第75个百分位数的变化与(，)标准差的认知分数的下降有关。我们的研究表明，砷可能是锰毒性的增强剂。使用一种新的统计方法来研究化学混合物对健康的影响，我们发现了混合物的神经毒性以及砷和锰之间潜在的协同作用的证据。Https://doi.org/10.1289/EHP614
Exposure to chemical mixtures is recognized as the real-life scenario in all populations, needing new statistical methods that can assess their complex effects. We aimed to assess the joint effect of in utero exposure to arsenic, manganese, and lead on children’s neurodevelopment. We employed a novel statistical approach, Bayesian kernel machine regression (BKMR), to study the joint effect of coexposure to arsenic, manganese, and lead on neurodevelopment using an adapted Bayley Scale of Infant and Toddler Development™. Third Edition, in 825 mother–child pairs recruited into a prospective birth cohort from two clinics in the Pabna and Sirajdikhan districts of Bangladesh. Metals were measured in cord blood using inductively coupled plasma-mass spectrometry. Analyses were stratified by clinic due to differences in exposure profiles. In the Pabna district, which displayed high manganese levels [interquartile range (IQR): 4.8, ], we found a statistically significant negative effect of the mixture of arsenic, lead, and manganese on cognitive score when cord blood metals concentrations were all above the 60th percentile (, , ) compared to the median (, , ). Evidence of a nonlinear effect of manganese was found. A change in log manganese from the 25th to the 75th percentile when arsenic and manganese were at the median was associated with a decrease in cognitive score of (, ) standard deviations. Our study suggests that arsenic might be a potentiator of manganese toxicity. Employing a novel statistical method for the study of the health effects of chemical mixtures, we found evidence of neurotoxicity of the mixture, as well as potential synergism between arsenic and manganese. https://doi.org/10.1289/EHP614