DETERMINANTS OF ECHOCARDIOGRAPHIC AORTIC ROOT SIZE - THE FRAMINGHAM HEART-STUDY
DETERMINANTS OF ECHOCARDIOGRAPHIC AORTIC ROOT SIZE - THE FRAMINGHAM HEART-STUDY
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DOI：
10.1161/01.cir.91.3.734
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发表时间：
1995-02-01
期刊：
影响因子：
37.8
通讯作者：
LEVY, D
中科院分区：
文献类型：
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作者：
VASAN, RS;LARSON, MG;LEVY, D
背景以前的研究评价了主动脉根部大小的决定因素，但没有得出统一的结果。我们研究了年龄，身高，体重，体表面积，性别和血压的关系，以超声心动图确定的主动脉根部大小在一个人口为基础的cohol.Methods和结果的研究样本包括1849名男性和2152名女性的心脏Frachearts研究和Frachearts后代研究谁是Gee的临床明显的心脏疾病时，超声心动图进行。采用前缘对前缘技术，通过M型超声心动图测量主动脉根部。年龄、身高、体重、体表面积和血压变量（当代和8年前获得的）与主动脉根尺寸的关系通过使用性别特异性相关性和线性回归分析进行了检查。年龄、身高;体重和性别是成人主动脉根部尺寸的主要决定因素（男性累积R（2）= 0.2085，女性为0.2327）。同期或既往血压测量的额外影响很小，并显示主动脉根部尺寸与平均动脉压和舒张压直接相关，与脉搏压和收缩压反向相关。一旦当代血压变量进入模型，以前的血压测量结果对主动脉根部大小的预测没有显着贡献。使用性别汇总数据集进行回归分析的结果显示，平均而言，女性的主动脉根部测量值比年龄、身高和体重相当的男性小2.4 mm。根据血压水平，使用逻辑回归来评估主动脉根部扩大的可能性。校正年龄、身高和体重后，收缩压增加1个标准差，主动脉扩张的优势比为0.70（95% CI，0.52 - 0.95），男性为0.79女性（95% CI，0.60 - 1.04）;舒张压增加1个标准差的比值比为1.22结论年龄、身高、体重和性别是影响主动脉根部大小的主要因素。血压测量的额外影响很小;观察到主动脉根部尺寸与平均动脉压和舒张压的直接相关性以及与脉搏和收缩压的反向相关性。需要进一步的前瞻性研究来证实这些观察结果，并评估主动脉根部尺寸对高血压发病率的影响。
Background Previous studies that evaluated the determinants of aortic root size have not yielded uniform results. We examined the relations of age, height, weight, body surface area, sex, and blood pressure to echocardiographically determined aortic root size in a population-based cohort.Methods and Results The study sample consisted of 1849 men and 2152 women in the Framingham Heart Study and Framingham Offspring Study who were Gee of clinically apparent cardiac disease when echocardiography was performed. Aortic root measurements were made by M-mode echocardiography using a leading-edge-to-leading-edge technique. The relations of age, height, weight, body surface area, and blood pressure variables (contemporary and those obtained 8 years before) to aortic root dimension were examined by use of sex-specific correlations and linear regression analyses. Age, height; weight, and sex emerged as the principal determinants of aortic root dimensions in adults (cumulative R(2)=.2085 in men and .2327 in women). The additional effect of contemporary or previous blood pressure measures was small and revealed direct associations of aortic root dimension with mean arterial and diastolic blood pressures and inverse associations with pulse and systolic blood pressures. Previous blood pressure measurements did not contribute significantly to prediction of aortic root size once contemporary blood pressure variables entered the models. Results of regression analyses using a sex-pooled data set showed that on average, the aortic root measurement in women was 2.4 mm smaller than that of men of comparable age, height, and weight. Logistic regression was used to assess the likelihood of aortic root enlargement according to blood pressure levels. After adjustment for age, height, and weight, the odds ratio of aortic dilation for a 1-SD increment in systolic pressure was 0.70 (95% CI, 0.52 to 0.95) in men and 0.79 (95% CI, 0.60 to 1.04) in women; the odds ratio for a 1-SD increment in diastolic pressure was 1.22 (95% CI, 0.91 to 1.63) in men and 1.33 (95% CI, 1.01 to 1.73) in women.Conclusions Age, height, weight, and sex emerged as the principal determinants of aortic root dimensions. The additional influences of blood pressure measurements were small; direct associations of aortic root dimensions with mean arterial and diastolic blood pressures and inverse associations with pulse and systolic blood pressures were observed. Additional prospective studies are needed to confirm these observations and to assess the impact of aortic root dimensions on the incidence of hypertension.