Omega-3 and omega-6 fatty acid exposure from early life does not affect atopy and asthma at age 5 years
Omega-3 and omega-6 fatty acid exposure from early life does not affect atopy and asthma at age 5 years
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DOI：
10.1016/j.jaci.2007.01.046
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发表时间：
2007-06-01
影响因子：
14.2
通讯作者：
Marks, Guy B.
中科院分区：
文献类型：
--
作者：
Almqvist, Catarina;Garden, Frances;Marks, Guy B.
背景：儿童哮喘预防研究是一项随机对照试验，在有哮喘家族史的儿童中进行，这些儿童补充omega-3脂肪酸和限制饮食中的omega-6脂肪酸并不能预防5岁时的哮喘、湿疹或特应性湿疹。目的：我们试图在整个出生队列中检查所有omega-3和omega-6多不饱和脂肪酸与5岁时结局的关系，而不考虑随机分组。方法：分别在18个月、3岁和5岁时测定血浆脂肪酸。每6个月对脂肪酸补充剂的依从性进行评估。在18个月时通过称重食物记录评估饮食摄入量，3岁时通过食物频率问卷评估饮食摄入量。在5岁时，516名儿童接受了喘息和湿疹（问卷调查）和特应性反应（皮肤点刺试验，n = 488）的检查。多元逻辑回归用于评估暴露与结果之间的关联。结果：5岁时，血浆中omega-3或omega-6脂肪酸水平与哮喘、湿疹或特应性反应无关（P = 0.11 - 0.96）。总的来说，脂肪酸暴露（以血浆水平、膳食摄入量和补充剂依从性来衡量）与任何呼吸或过敏结果无关（P = 0.35 - 0.59）。结论：该队列的观察性分析，使用观察到的ω -3和ω -6脂肪酸暴露的全范围变化，支持随机对照试验的阴性结果。临床意义：幼儿饮食中多不饱和脂肪酸的改变对预防特应性和哮喘没有帮助。
Background: The Childhood Asthma Prevention Study was a randomized controlled trial conducted in children with a family history of asthma in whom omega-3 fatty acid supplementation and restriction of dietary omega-6 fatty acids did not prevent asthma, eczema, or atopy at age 5 years.Objective: We sought to examine the relation of all measures of omega-3 and omega-6 polyunsaturated fatty acids with outcomes at age 5 years in the whole birth cohort, regardless of randomization group.Methods: Plasma fatty acids were measured at 18 months, 3 years, and 5 years. Compliance with the fatty acid supplements was estimated every 6 months. Dietary intake was assessed at 18 months by means of weighed-food record and at 3 years by means of food-frequency questionnaire. At age 5 years, 516 children were examined for wheeze and eczema (questionnaire) and atopy (skin prick tests, n = 488). Multiple logistic regression was used to evaluate associations between exposures and outcomes.Results: Plasma levels of omega-3 or omega-6 fatty acids were not associated with wheeze, eczema, or atopy at age 5 years (P = .11-.96). Overall, fatty acid exposure, measured as plasma levels, dietary intake, and compliance with supplements, was not associated with any respiratory or allergic outcomes (P =.35-.59).Conclusion: This observational analysis of the cohort, using the full range of observed variation in omega-3 and omega-6 fatty acid exposure, supports the negative findings of the randomized controlled trial.Clinical implications: Modification of dietary polyunsaturated fatty acids in early childhood is not helpful in preventing atopy and asthma.