The possible role of tumor necrosis factor-alpha in diabetic polyneuropathy.
The possible role of tumor necrosis factor-alpha in diabetic polyneuropathy.
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DOI：
10.1155/edr.2003.65
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发表时间：
2003-04
期刊：
影响因子：
--
通讯作者：
Toyota T
中科院分区：
文献类型：
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作者：
Satoh J;Yagihashi S;Toyota T
本文就肿瘤坏死因子-α（TNF-α）在糖尿病并发症尤其是糖尿病多发性神经病发病中的作用进行综述。在慢性高血糖状态下，微血管和神经组织中内源性TNF-α的产生加速，可能发生微血管通透性增加、高凝状态和神经损伤，从而引发和促进糖尿病微血管病和多发性神经病的特征性病变的发展。TNF-α产生的增加也可能由于胰岛素抵抗和粘附分子表达的增加而促进动脉粥样硬化。临床应用特异性抑制TNF-α产生和/或活性的药物可能会抑制糖尿病慢性并发症的发生和加重。
In this review, the authors provide evidences that imply the role of tumor necrosis factor-α (TNF-α) in the pathogenesis of diabetic complications, especially diabetic polyneuropathy. Under chronic hyperglycemia, endogenous TNF-α production is accelerated in microvascular and neural tissues, which may undergo an increased microvascular permeability, hypercoagulability, and nerve damage, thus initiating and promoting the development of characteristic lesions of diabetic microangiopathy and polyneuropathy. Enhanced TNF-α production may also promote atherosclerosis due to increased insulin resistance and the expression of adhesion molecules. Clinical application of specific agents that suppress production and/or activity of TNF-α may inhibit the development and exacerbation of chronic diabetic complications.