Need for Standardization of 18F-FDG PET/CT for Treatment Response Assessments
Need for Standardization of 18F-FDG PET/CT for Treatment Response Assessments
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DOI：
10.2967/jnumed.110.085662
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发表时间：
2011-12-01
影响因子：
9.3
通讯作者：
Boellaard, Ronald
中科院分区：
文献类型：
--
作者：
Boellaard, Ronald
许多因素影响F-18-FDG PET/CT的标准化摄取值（SUV）。在多中心研究中使用单次PET扫描的SUV需要F-18-FDG PET/CT程序的标准化。在治疗反应评估（重复PET扫描）的背景下，许多因素似乎对SUV的百分比变化具有微小影响，前提是以一致的方式对每例受试者执行成像程序。然而，以非标准化方式使用F-18-FDG PET/CT将导致SUV和基于SUV的响应措施的未知偏倚和可重复性。本文概述了在治疗反应评估研究中与SUV的具体使用和SUV变化相关的标准化需求。
Many factors affect standardized uptake values (SUVs) in F-18-FDG PET/CT. The use of the SUV from a single PET scan in multicenter studies requires the standardization of F-18-FDG PET/CT procedures. In the context of treatment response assessments (repeated PET scans), many factors may seem to have minor effects on percentage changes in SUVs, provided that imaging procedures are executed in a consistent manner for each subject. However, the use of F-18-FDG PET/CT in a nonstandardized manner will result in unknown biases and reproducibilities of SUVs and SUV-based response measures. This article provides an overview of the need for standardization in relation to the specific use of SUVs and SUV changes in studies of treatment response assessments.