Development of a Two-Dimensional Model for Predicting Transdermal Permeation with the Follicular Pathway: Demonstration with a Caffeine Study.
Development of a Two-Dimensional Model for Predicting Transdermal Permeation with the Follicular Pathway: Demonstration with a Caffeine Study.
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DOI：
10.1007/s11095-017-2209-0
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发表时间：
2017-10
影响因子：
3.7
通讯作者：
Chen T
中科院分区：
文献类型：
--
作者：
Kattou P;Lian G;Glavin S;Sorrell I;Chen T
提出了一种新的二维（2D）模型来预测卵泡渗透，并将其整合到最近报道的透皮渗透多尺度模型中。卵泡通路是通过皮脂中的扩散来模拟的。脂质、角质层、活真皮、真皮和体循环中溶质的传质和分配特性按先前报道计算[Pharm Res 33(2016) 1602]。皮脂的传质和分割特性收集自现有文献。所有的模型输入参数都不适合与模型预测相比较的临床数据。该综合模型已被用于预测已发表的咖啡因透皮渗透的临床数据。分析了卵泡通路的相对重要性。模型预测与临床数据吻合较好。模拟证实，对于咖啡因，滤泡途径是重要的；据预测，毛囊开放时体循环中咖啡因的最大生物利用浓度比毛囊堵塞时高20%。卵泡途径不仅具有短时间快速渗透的特点，而且具有整体的全身生物利用度。利用这种硅模型，可以获得咖啡因在脂质、角质层、活真皮、真皮层和毛囊中的配置和局部递送的有用信息。如此详细的信息很难通过实验获得。
The development of a new two-dimensional (2D) model to predict follicular permeation, with integration into a recently reported multi-scale model of transdermal permeation is presented. The follicular pathway is modelled by diffusion in sebum. The mass transfer and partition properties of solutes in lipid, corneocytes, viable dermis, dermis and systemic circulation are calculated as reported previously [Pharm Res 33 (2016) 1602]. The mass transfer and partition properties in sebum are collected from existing literature. None of the model input parameters was fit to the clinical data with which the model prediction is compared. The integrated model has been applied to predict the published clinical data of transdermal permeation of caffeine. The relative importance of the follicular pathway is analysed. Good agreement of the model prediction with the clinical data has been obtained. The simulation confirms that for caffeine the follicular route is important; the maximum bioavailable concentration of caffeine in systemic circulation with open hair follicles is predicted to be 20% higher than that when hair follicles are blocked. The follicular pathway contributes to not only short time fast penetration, but also the overall systemic bioavailability. With such in silico model, useful information can be obtained for caffeine disposition and localised delivery in lipid, corneocytes, viable dermis, dermis and the hair follicle. Such detailed information is difficult to obtain experimentally.
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影响因子：
3.7
作者：
Chen, Longjian;Lian, Guoping;Han, Lujia
通讯作者：
Han, Lujia
影响因子：
3.7
作者：
Chen, Longjian;Han, Lujia;Lian, Guoping
通讯作者：
Lian, Guoping
影响因子：
3
作者：
Bookout, R L Jr;McDaniel, C R;McDougal, J N
通讯作者：
McDougal, J N
影响因子：
2.7
作者：
Hindmarsh, AC;Brown, PN;Woodward, CS
通讯作者：
Woodward, CS
影响因子：
4.6
作者：
Grams, YY;Alaruikka, S;Bouwstra, JA
通讯作者：
Bouwstra, JA