The effects of ruthenium red, an inhibitor of calcium-induced calcium release, on phasic myometrial contractions.
The effects of ruthenium red, an inhibitor of calcium-induced calcium release, on phasic myometrial contractions.
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钌红（钙诱导的钙释放抑制剂）对阶段性子宫肌层收缩的影响。
DOI：
10.1006/bbrc.1996.0652
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Basa,A
中科院分区：
文献类型：
--
作者：
Phillippe,M;Basa,A
钌红抑制钙诱导的钙释放从ryanodine敏感的细胞内钙库，本研究旨在评估钌红激动剂刺激的阶段性子宫肌收缩的影响。钌红可明显抑制催产素、前列腺素F2α、氟化铝、氯化钾、离子霉素和Bay K 8644引起的离体收缩。这些观察结果为以下假设提供了支持：在激动剂刺激的阶段性子宫肌层收缩期间，钙诱导的钙从ryanodine敏感的钙库中释放是一个重要事件。
Ruthenium red inhibits calcium-induced calcium release from the ryanodine-sensitive intracellular calcium stores; this study sought to evaluate the effects of ruthenium red on agonist-stimulated phasic myometrial contractions. Ruthenium red was found to significantly inhibitin vitroisometric contractions stimulated in response to oxytocin, prostaglandin F2α,aluminum fluoride, potassium chloride, ionomycin, and Bay K 8644. These observations provide support for the hypothesis that calcium-induced calcium release from ryanodine-sensitive calcium stores is an important event during agonist-stimulated phasic myometrial contractions.