Respiratory functional and motor control deficits in children with spinal cord injury.
Respiratory functional and motor control deficits in children with spinal cord injury.
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DOI：
10.1016/j.resp.2017.10.006
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发表时间：
2018-01
影响因子：
2.3
通讯作者：
Ovechkin AV
中科院分区：
文献类型：
--
作者：
Singh G;Behrman AL;Aslan SC;Trimble S;Ovechkin AV
脊髓损伤（SCI）的儿童由于呼吸运动控制缺陷而具有发生并发症的高风险。然而，这些异常与年龄发育和损伤特征的潜在机制尚不清楚。为了评估脊髓损伤和年龄对脊髓损伤儿童呼吸运动控制的影响，我们比较了健康典型发育（TD）儿童与年龄匹配的慢性脊髓损伤儿童的肺功能和呼吸运动控制结果。我们假设脊髓损伤儿童呼吸功能的缺陷是由于呼吸肌激活模式的异常和年龄依赖性。14例TD（年龄7 ± 2岁，平均值±标准差）和12名SCI儿童（年龄6 ± 1岁）通过评估用力肺活量（FVC）、1秒用力呼气量（FEV1）和最大吸气和最大呼气气道压测量期间的呼吸肌电图活动（PImax和PEmax）进行评价。结果表明，与TD对照组相比，SCI儿童的FVC、FEV1和PEmax值显著降低（p<0.01）。在PEmax评估期间，SCI儿童在神经损伤水平以下（腹直肌和外斜肌）的呼吸肌激活显著降低（p<0.01）。此外，SCI儿童在损伤水平（上阔肌）以上的代偿性肌肉激活显著增加（p<0.05）。在TD组中，年龄、身高和体重对FVC和FEV1的增加有显著影响（p<0.05）。在SCI儿童中，只有年龄与FVC和FEV1值显著相关（p<0.05）。这些发现表明SCI引起的儿童呼吸功能和运动控制缺陷的程度具有年龄依赖性。
Children with spinal cord injury (SCI) are at high risk for developing complications due to respiratory motor control deficits. However, underlying mechanisms of these abnormalities with respect to age development and injury characteristics are unclear. To evaluate the effect of SCI and age on respiratory motor control in children with SCI, we compared pulmonary function and respiratory motor control outcome measures in healthy typically developing (TD) children to age-matched children with chronic SCI. We hypothesized that the deficits in respiratory functional performance in children with SCI are due to the abnormal and age-dependent respiratory muscle activation patterns. Fourteen TD (age 7 ± 2 yrs., Mean ± SD) and twelve children with SCI (age 6 ± 1 yrs.) were evaluated by assessing Forced Vital Capacity (FVC); Forced Expiratory Volume in 1sec (FEV1); and respiratory electromyographic activity during maximum inspiratory and maximum expiratory airway pressure measurements (PImax and PEmax). The results indicate a significant reduction (p<.01) of FVC, FEV1 and PEmax values in children with SCI compared to TD controls. During PEmax assessment, children with SCI produced significantly decreased (p<.01) activation of respiratory muscles below the neurological level of injury (rectus abdominous and external oblique muscles). In addition, children with SCI had significantly increased (p<.05) compensatory muscle activation above the level of injury (upper trapezius muscle). In the TD group, age, height and weight have significantly (p<.05) contributed towards increase in FVC and FEV1. In children with SCI, only age was significantly (p<.05) correlated with FVC and FEV1 values. These findings indicate the degree of SCI-induced respiratory functional and motor control deficits in children are age-dependent.
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影响因子：
1.7
作者：
Chng, SY;Wong, YQ;Goh, DY
通讯作者：
Goh, DY
影响因子：
2.3
作者：
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通讯作者：
Lorenz, Douglas
DOI：
10.1016/j.apmr.2006.06.015
发表时间：
2006-10-01
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Birnkrant, DJ
影响因子：
2
作者：
HOLSTEGE, G;VANNEERVEN, J;EVERTSE, F
通讯作者：
EVERTSE, F