One‐step synthesis of 6‐acetamido‐3‐(N‐(2‐(dimethylamino) ethyl) sulfamoyl) naphthalene‐1‐yl 7‐acetamido‐4‐hydroxynaphthalene‐2‐sulfonate and its characterization with 1D and 2D NMR techniques
One‐step synthesis of 6‐acetamido‐3‐(N‐(2‐(dimethylamino) ethyl) sulfamoyl) naphthalene‐1‐yl 7‐acetamido‐4‐hydroxynaphthalene‐2‐sulfonate and its characterization with 1D and 2D NMR techniques
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DOI：
10.1002/mrc.3955
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发表时间：
2013-07
影响因子：
2
通讯作者：
Wei Zhang
中科院分区：
文献类型：
--
作者：
Wei Zhang
报道了在K2CO3存在下，用等摩尔N， N -二甲基乙二胺在乙腈中处理7 -乙酰氨基- 4 -羟基- 2 -萘磺酰氯，一步法合成6 -乙酰氨基- 3 - （N - 2 -（二甲氨基）乙基）磺胺基)萘- 1 -基7 -乙酰氨基- 4 -羟基- 2 -磺酸盐。通过MS、FTIR、1H NMR、13C NMR、gCOSY、TOCSY、gHSQC、gHMBC等手段对所得化合物的化学结构进行了表征。1H和13C的化学位移差分别为δ 0.04和0.2。版权所有©2013 John Wiley & Sons， Ltd
A one‐step method was reported for the synthesis of 6‐acetamido‐3‐(N‐(2‐(dimethylamino) ethyl) sulfamoyl) naphthalene‐1‐yl 7‐acetamido‐4‐hydroxynaphthalene‐2‐sulfonate by treating 7‐acetamido‐4‐hydroxy‐2‐naphthalenesulfonyl chloride with equal moles of N, N‐dimethylethylenediamine in acetonitrile in the presence of K2CO3. The chemical structure of the obtained compounds was characterized by MS, FTIR, 1H NMR, 13C NMR, gCOSY, TOCSY, gHSQC, and gHMBC. The chemical shift differences of 1H and 13C being δ 0.04 and 0.2, respectively, were unambiguously differentiated. Copyright © 2013 John Wiley & Sons, Ltd.