Role of medullary inspiratory neurones in the control of the diaphragm during oesophageal stimulation in cats.
Role of medullary inspiratory neurones in the control of the diaphragm during oesophageal stimulation in cats.
复制标题
延髓吸气神经元在猫食道刺激过程中控制膈肌的作用。
DOI：
10.1113/jphysiol.1987.sp016738
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Pack,AI
中科院分区：
文献类型：
--
作者：
Altschuler,SM;Davies,RO;Pack,AI
1.记录了食道扩张和吞咽对去脑自发呼吸猫延髓呼吸神经元活动的影响。通过在食道的胸段充气气囊所产生的扩张，足以引起对隔脚的食道周围部分的抑制，而对以膈神经C5支的活动来衡量的隔膜的呼吸功能几乎没有影响。2.对424个神经元进行测试。它们位于双侧孤束核区(呼吸背侧组)或疑似复合体(呼吸腹侧组)。在扩张或吞咽引起的脚部电活动强烈抑制期间，没有细胞表现出活性的变化。所有细胞的活动与C5膈神经图的活动平行，这不受测试的影响。3.我们得出结论：食道扩张时隔脚反射的抑制不是由于背侧和腹侧的延髓运动前吸气神经元受到抑制所致。在胃肠道反射时，必须存在其他中枢通路，以抑制运动神经元到达脚横隔膜。
1. The effect of oesophageal distension and swallowing on the activity of medullary respiratory neurones was recorded in decerebrate, spontaneously breathing cats. The distension, produced by inflating a balloon in the thoracic portion of the oesophagus, was of sufficient magnitude to induce inhibition of the peri‐oesophageal part of the crural diaphragm, with little effect on the respiratory function of the diaphragm as measured by the activity in the C5 branch of the phrenic nerve. 2. 424 neurones were tested. They were located bilaterally, in the region of the nucleus tractus solitarius (dorsal respiratory group) or the ambiguous complex (ventral respiratory group). No cell exhibited a change in activity during periods of strong inhibition of crural electrical activity induced by distension or swallowing. The activity of all cells paralleled that of the C5 phrenic neurogram, which was unaffected by the tests. 3. We conclude that the reflex inhibition of the crural diaphragm during oesophageal distension does not result from an inhibition of medullary premotor inspiratory neurones of the dorsal and ventral groups. Additional central pathways must exist that inhibit motoneurones to the crural diaphragm during gastrointestinal reflexes.