Substituted spiro [2.3′] oxindolespiro [3.2"]-5,6-dimethoxy-indane-1"-one-pyrrolidine analogue as inhibitors of acetylcholinesterase
Substituted spiro [2.3′] oxindolespiro [3.2"]-5,6-dimethoxy-indane-1"-one-pyrrolidine analogue as inhibitors of acetylcholinesterase
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DOI：
10.1016/j.bmcl.2010.09.108
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发表时间：
2010-12-01
影响因子：
2.7
通讯作者：
Manogaran, Elumalai
中科院分区：
文献类型：
--
作者：
Ali, Mohamed Ashraf;Ismail, Rusli;Manogaran, Elumalai
合成了一系列吡咯烷类似物并作为乙酰胆碱酯酶 (AChE) 抑制剂进行了研究。在这些化合物中，化合物4k和6k是该系列中最有效的抑制剂。化合物4k对乙酰胆碱酯酶表现出有效的抑制活性，IC(50)为0.10 mu mol/L。吡咯烷类似物可能是治疗 AD 的潜在乙酰胆碱酯酶药物。 (C) 2010 Elsevier Ltd. 保留所有权利。
Series of pyrolidine analogues were synthesized and examined as acetylcholinesterase (AChE) inhibitors. Among the compounds, compounds 4k and 6k were the most potent inhibitors of the series. Compound 4k, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC(50) 0.10 mu mol/L. Pyrolidine analogues might be potential acetyl cholinesterase agents for AD. (C) 2010 Elsevier Ltd. All rights reserved.