Impact of green tea on the deleterious cardiometabolic effects of 7-days unhealthy lifestyle in young healthy males.
Impact of green tea on the deleterious cardiometabolic effects of 7-days unhealthy lifestyle in young healthy males.
复制标题
绿色茶对年轻健康男性7天不健康生活方式有害心脏代谢影响的影响。
DOI：
10.14814/phy2.14720
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发表时间：
2021-03
影响因子：
2.5
通讯作者：
Low DA
中科院分区：
文献类型：
--
作者：
Roberts KA;Draijer R;Hopkins ND;de Graaf Y;Holder SM;Carter SE;Thijssen DHJ;Low DA
这项研究的目的是检查富含儿茶素的绿茶是否能消除7天不运动和过量摄入卡路里对胰岛素稳态和外周血管功能的负面影响。采用随机、双盲、交叉设计，12名健康男性(29±16.6岁)经历了7天的不健康生活方式(UL)，包括运动不足(−50%步数/天)和过量进食(+50%千卡/天)。这与绿茶消费(UL-茶；每天3剂)或安慰剂(UL-安慰剂)相结合。在每次干预前后，我们检测了餐后血糖和胰岛素(1,202千卡的餐后3小时)以及上下肢血管功能(血流介导的扩张(FMD%))和颈动脉反应性(CAR%)。UL-安慰剂增加餐后血糖和胰岛素，而UL-TEA降低餐后血糖和胰岛素(时间*干预交互作用：两者均P<0.05)。UL-安慰剂降低了CAR%和股骨FMD%，而UL-TEA则阻止了这些影响(分别为0.04%和0.001的时间×干预交互效应)。时间或时间*干预交互作用(P<0.05)对臂部FMD%没有主效应。七天的不运动和过度进食会破坏胰岛素的稳态和血管功能。每天摄入富含儿茶素的绿茶可以缓解这些影响。这项研究的目的是检查富含儿茶素的绿茶是否能消除短期缺乏体育活动和过量摄入卡路里对胰岛素稳态和外周血管功能的负面影响。12名健康男性(29岁±16.6岁)接受了7天的不健康生活方式(UL)，包括运动不足(−50%步数/天)和过度进食(+50%千卡/天)，同时饮用绿茶(UL-茶；3个剂量/天)或安慰剂(UL-安慰剂)。UL-安慰剂增加餐后血糖和胰岛素，而UL-TEA降低餐后血糖和胰岛素。UL-安慰剂降低颈动脉反应性和下肢血管功能，而UL-TEA则阻止这些影响。每天摄入富含儿茶素的绿茶，可以缓解七天的身体不活动和过量喂养导致的胰岛素稳态和血管功能损害。
The aim of this study was to examine if catechin‐rich green tea abrogates the negative effects of 7‐days of physical inactivity and excessive calorie‐intake on insulin homeostasis and peripheral vascular function. Using a randomized, double‐blind, crossover design, twelve healthy men (29 ± 6 yrs) underwent 7‐days unhealthy lifestyle (UL), including physical inactivity (−50% steps/day) and overfeeding (+50% kcal/day). This was combined with green tea consumption (UL‐tea; 3 doses/day) or placebo (UL‐placebo). Before and after each intervention, we examined postprandial blood glucose and insulin (3‐h after a 1,202 kcal meal) and upper and lower limb vascular function (flow‐mediated dilation (FMD%)) and carotid artery reactivity (CAR%). UL‐placebo increased postprandial glucose and insulin, while UL‐tea decreased postprandial glucose and insulin (Time*Intervention interaction effects: both p < 0.05). UL‐placebo decreased CAR% and femoral FMD%, while UL‐tea prevented these effects (Time*Intervention interaction effects of p < 0.04 and p < 0.001, respectively). There was no main effect of Time or Time*Intervention interaction (both p > 0.05) for brachial FMD%. Seven days of physical inactivity and overfeeding impair insulin homeostasis and vascular function. These effects were mitigated by a daily intake of catechin‐rich green tea. The aim of this study was to examine if catechin‐rich green tea abrogates the negative effects of short‐term physical inactivity and excessive calorie‐intake on insulin homeostasis and peripheral vascular function. Twelve healthy men (29 ± 6 yrs) underwent 7‐days unhealthy lifestyle (UL), including physical inactivity (−50% steps/day) and overfeeding (+50% kcal/day) combined with green tea consumption (UL‐tea; 3 doses/day) or placebo (UL‐placebo). UL‐placebo increased post‐prandial glucose and insulin, while UL‐tea decreased post‐prandial glucose and insulin. UL‐placebo decreased carotid artery reactivity and lower limb vascular function, while UL‐tea prevented these effects. Seven days of physical inactivity‐ and overfeeding‐induced impairments in insulin homeostasis and vascular function were mitigated by daily intake of catechin‐rich green tea.