Molecular neuropathology of gliomas.

Molecular neuropathology of gliomas.
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DOI:
10.3390/ijms10010184
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发表时间:
2009-01
影响因子:
5.6
通讯作者:
Reifenberger G
Reifenberger G
中科院分区:
生物学2区
文献类型:
--
作者:
Riemenschneider MJ;Reifenberger G

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胶质瘤是人类最常见的原发性脑肿瘤。根据世界卫生组织(WHO)对神经系统肿瘤的分类,它们包括一组异质性的良性和恶性肿瘤。在过去20年中,人们对与胶质瘤形成和进展相关的细胞遗传学和分子遗传学改变进行了深入研究,并将遗传谱作为脑肿瘤定义的额外辅助工具纳入世卫组织分类。事实上,通过使用分子测试来补充经典的组织病理学诊断已经迈出了第一步,例如胶质母细胞瘤中的MGMT启动子超甲基化或少突胶质肿瘤中染色体臂1p和19q缺失的检测。在使用基于阵列的分析技术方面取得的巨大进展可能有助于进一步完善胶质瘤的分子分类,并导致胶质瘤核心途径的鉴定,这些途径可以通过更个性化的胶质瘤治疗来特异性靶向。
Gliomas are the most common primary human brain tumors. They comprise a heterogeneous group of benign and malignant neoplasms that are histologically classified according to the World Health Organization (WHO) classification of tumors of the nervous system. Over the past 20 years the cytogenetic and molecular genetic alterations associated with glioma formation and progression have been intensely studied and genetic profiles as additional aids to the definition of brain tumors have been incorporated in the WHO classification. In fact, first steps have been undertaken in supplementing classical histopathological diagnosis by the use of molecular tests, such as MGMT promoter hypermethylation in glioblastomas or detection of losses of chromosome arms 1p and 19q in oligodendroglial tumors. The tremendous progress that has been made in the use of array-based profiling techniques will likely contribute to a further molecular refinement of glioma classification and lead to the identification of glioma core pathways that can be specifically targeted by more individualized glioma therapies.
DOI: 10.1002/gcc.10087
发表时间: 2002-08-01
影响因子: 3.7
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