Effect of thyroid hormones on the activities of hepatic alcohol metabolizing enzymes.
Effect of thyroid hormones on the activities of hepatic alcohol metabolizing enzymes.
复制标题
甲状腺激素对肝脏酒精代谢酶活性的影响。
DOI：
10.1016/0006-291x(79)91850-3
复制
发表时间：
1979
影响因子：
3.1
通讯作者：
G. Strohmeyer
中科院分区：
文献类型：
--
作者：
F. Moreno;R. Teschke;G. Strohmeyer
用甲状腺素或三碘甲状腺原氨酸处理7天以模拟甲状腺功能亢进状态，导致微粒体乙醇氧化系统的活性增强。相反，在这些实验条件下观察到肝醇脱氢酶活性降低，而肝过氧化氢酶活性保持不变。这些研究结果表明，如果慢性乙醇消耗模拟“甲状腺功能亢进的肝脏状态”，增加乙醇代谢率观察后，长期饮酒，因此可能至少部分归因于诱导微粒体乙醇氧化系统的活性在肝脏中。
Treatment with thyroxine or triiodothyronine for 7 days in order to simulate a hyperthyroid state results in an enhanced activity of the microsomal ethanol oxidizing system. Conversely, a decrease of hepatic alcohol dehydrogenase activity was observed under these experimental conditions, whereas hepatic catalase activity remained unchanged. These findings suggest that if chronic ethanol consumption simulates a “hyperthyroid hepatic state”, increased rates of ethanol metabolism observed following prolonged alcohol intake might therefore be attributed at least in part to an induction of microsomal ethanol oxidizing system activity in the liver.