Mindfulness Intervention Decreases Frequency and Severity of Flares in Inactive Ulcerative Colitis Patients: Results of a Phase II, Randomized, Placebo-Controlled Trial.
Mindfulness Intervention Decreases Frequency and Severity of Flares in Inactive Ulcerative Colitis Patients: Results of a Phase II, Randomized, Placebo-Controlled Trial.
复制标题
正念干预可降低非活动性溃疡性结肠炎患者发作的频率和严重程度：II 期随机安慰剂对照试验的结果。
DOI：
10.1093/ibd/izac036
复制
发表时间：
2022
影响因子：
4.9
通讯作者：
Keshavarzian,Ali
中科院分区：
文献类型：
--
作者：
Jedel,Sharon;Beck,Todd;Swanson,Garth;Hood,MeganM;Voigt,RobinM;Gorenz,Annika;Jakate,Shriram;Raeisi,Shohreh;Hobfoll,Stevan;Keshavarzian,Ali
背景溃疡性结肠炎（UC）是一种慢性炎症性疾病，其特征为有症状期（发作期）和无症状期（缓解期）。有证据表明，心理压力可以引发耀斑。研究表明，正念干预（MI）可以减轻压力，促进更适应性的应对，提高生活质量，但对UC患者的使用很少。本研究的目的是确定是否参与MI的结果在改善UC疾病的过程和炎症级联反应，正念，感知压力，和其他心理结果在非活动性UC患者与有限或没有接触到过去MI。MethodsParticipants被随机分配到一个8周的MI或对照组。生物和心理评估进行了基线，后8周的课程，并在6和12 months.ResultsForty-three参与者登记。MI增加了非活动性UC患者的正念状态和正念技能，降低了感知压力和压力反应。MI干预显著降低了12个月内发作的发生率（P<0.05）。没有UC患者在MI爆发在12个月内，而5 23（22%）对照组参与者爆发在同一period.ConclusionsMIs可以被认为是辅助治疗UC患者的一个子集，高感知压力和低状态的正念。该试验在clinicaltrials.gov注册为NCT 01491997。
BackgroundUlcerative Colitis (UC) is a chronic, inflammatory disease, characterized by symptomatic periods (flare) interspersed with asymptomatic periods (remission). Evidence suggests that psychological stress can trigger flare. Studies have shown that mindfulness interventions (MI) reduce stress, foster more adaptive coping, and improve quality of life, but have been minimally used for UC patients. The objective of this study was to determine whether participation in an MI results in improvements in UC disease course and inflammatory cascades, mindfulness, perceived stress, and other psychological outcomes in inactive UC patients with limited or no exposure to past MI.MethodsParticipants were randomized to an 8-week MI or control group. Biological and psychological assessments were performed at baseline, post 8-week course, and at 6- and 12-months.ResultsForty-three participants enrolled. The MI increased the state of mindfulness and mindfulness skills, decreased perceived stress and stress response in patients with inactive UC. The MI intervention significantly decreased the incidence of flare over 12 months (P< .05). None of the UC patients in the MI flared during 12 months, while 5 of 23 (22%) control group participants flared during the same period.ConclusionsMIs could be considered as adjuvant treatment for a subset of UC patients with high perceived stress and low state of mindfulness.The trial was registered at clinicaltrials.gov as NCT01491997.