LEUKOTRIENES PROMOTE PLASMA LEAKAGE AND LEUKOCYTE ADHESION IN POST-CAPILLARY VENULES - INVIVO EFFECTS WITH RELEVANCE TO THE ACUTE INFLAMMATORY RESPONSE
LEUKOTRIENES PROMOTE PLASMA LEAKAGE AND LEUKOCYTE ADHESION IN POST-CAPILLARY VENULES - INVIVO EFFECTS WITH RELEVANCE TO THE ACUTE INFLAMMATORY RESPONSE
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DOI：
10.1073/pnas.78.6.3887
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
SAMUELSSON, B
中科院分区：
文献类型：
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作者：
DAHLEN, SE;BJORK, J;SAMUELSSON, B
白三烯B4， C4和D4是最近发现的由花生四烯酸生物合成的物质家族的成员，在仓鼠颊袋中具有有效的微血管作用。当局部应用于血管网络时，白三烯C4和D4引起小动脉的强烈收缩，在这方面的效力与血管紧张素相似。白三烯C4和D4诱导的血管收缩是短暂的，随后持续出现明显的、剂量依赖性的大分子从毛细血管后小静脉外渗。组胺不收缩小动脉，但引起血浆渗漏，尽管在摩尔基础上，它的效力不超过白三烯的千分之一。在与白三烯C4和D4相同的浓度范围内使用时，白三烯B4不会引起血管收缩或促进血浆渗漏。白三烯B4引起白细胞与毛细血管后小静脉内皮明显的可逆粘附。白三烯在体内诱导微循环改变的研究结果，与急性炎症反应的早期事件非常相似，这意味着白三烯在几种血源性和组织结合细胞中形成，可能介导对有害刺激的重要微循环调节。
Leukotrienes B4, C4 and D4, members of a recently discovered family of substances biosynthesized from arachidonic acid, had potent microvascular actions in the hamster cheek pouch. When applied topically to the vascular network, leukotrienes C4 and D4 caused an intense constriction of arterioles, being similar to angiotensin in potency in this respect. The vasoconstriction induced by leukotrienes C4 and D4 was short-lived, and was consistently followed by a marked and dose-dependent extravasation of macromolecules from postcapillary venules. Histamine did not constrict arterioles but elicited leakage of plasma, although on a molar basis it was no more than 1/1000th as potent as the leukotrienes. When used in the same concentration range as leukotrienes C4 and D4, leukotriene B4 did not evoke vasoconstriction or promote plasma leakage. Leukotriene B4 caused a conspicuous and reversible adhesion of leukocytes to the endothelium in postcapillary venules. Findings that leukotrienes induce microcirculatory alterations in vivo, closely resembling the early events in the acute inflammatory response, imply that leukotrienes formed in several blood-borne and tissue-bound cells may mediate important microcirculatory adjustments to noxious stimuli.