COPD immunopathology.
COPD immunopathology.
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慢性阻塞性肺病免疫病理反应。
DOI：
10.1007/s00281-016-0561-5
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发表时间：
2016-07
影响因子：
9
通讯作者：
Adcock I
中科院分区：
文献类型：
--
作者：
Caramori G;Casolari P;Barczyk A;Durham AL;Di Stefano A;Adcock I
慢性阻塞性肺疾病(COPD)的免疫病理基础是慢性吸入香烟引起的先天和获得性炎症免疫反应。在本世纪最后四分之一个世纪，通过对COPD患者下呼吸道标本的分析，与年龄匹配、肺功能正常的对照组吸烟者的标本进行比较，对先天性和获得性免疫反应的不同细胞及其促炎/抗炎介质和细胞内信号通路的潜在致病作用提供了新的见解，有助于更好地了解COPD稳定期和恶化期间的免疫病理学。这也为新药发现和靶向下呼吸道提供了科学依据。本文对不同严重程度的COPD患者与肺功能正常的对照吸烟者的免疫病理学进行了总结和讨论。
The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette smoking. In the last quarter of the century, the analysis of specimens obtained from the lower airways of COPD patients compared with those from a control group of age-matched smokers with normal lung function has provided novel insights on the potential pathogenetic role of the different cells of the innate and acquired immune responses and their pro/anti-inflammatory mediators and intracellular signalling pathways, contributing to a better knowledge of the immunopathology of COPD both during its stable phase and during its exacerbations. This also has provided a scientific rationale for new drugs discovery and targeting to the lower airways. This review summarises and discusses the immunopathology of COPD patients, of different severity, compared with control smokers with normal lung function.