CD4+ T lymphocytes are not necessary for the acute rejection of vascularized mouse lung transplants
CD4+ T lymphocytes are not necessary for the acute rejection of vascularized mouse lung transplants
复制标题
DOI：
10.4049/jimmunol.180.7.4754
复制
发表时间：
2008-04-01
影响因子：
4.4
通讯作者：
Kreisel, Daniel
中科院分区：
文献类型：
--
作者：
Gelman, Andrew E.;Okazaki, Mikio;Kreisel, Daniel
急性排斥反应仍然是肺移植成功的主要障碍。尽管CD4(+)T淋巴细胞对于一些实体器官移植物的排斥反应至关重要，但CD4(+)T细胞在肺同种异体移植物排斥反应中的作用很大程度上尚不清楚。在本研究中，我们在原位血管化小鼠肺移植的新模型中证明，同种异体肺移植物的急性排斥不依赖于CD4（+）T细胞介导的同种异体识别途径。 CD4(+) T 细胞非依赖性排斥反应发生在缺乏供体来源的移植物驻留造血 APC 的情况下。此外，阻断CD28/B7共刺激通路可减弱CD4+T细胞不存在时的急性肺同种异体移植排斥反应，但在CD4+T细胞存在时不会延迟急性排斥反应。我们的结果为肺同种异体移植物的急性排斥提供了新的机制见解，并强调了识别调节各种器官排斥的途径差异的重要性。
Acute rejection continues to present a major obstacle to successful lung transplantation. Although CD4(+) T lymphocytes are critical for the rejection of some solid organ grafts, the role of CD4(+) T cells in the rejection of lung allografts is largely unknown. In this study, we demonstrate in a novel model of orthotopic vascularized mouse lung transplantation that acute rejection of lung allografts is independent of CD4(+) T cell-mediated allorecognition pathways. CD4(+) T cell-independent rejection occurs in the absence of donor-derived graft-resident hematopoietic APCs. Furthermore, blockade of the CD28/B7 costimulatory pathways attenuates acute lung allograft rejection in the absence of CD4(+) T cells, but does not delay acute rejection when CD4(+) T cells are present. Our results provide new mechanistic insight into the acute rejection of lung allografts and highlight the importance of identifying differences in pathways that regulate the rejection of various organs.