Material properties of subchondral bone from patients with osteoporosis or osteoarthritis by microindentation testing and electron probe microanalysis
Material properties of subchondral bone from patients with osteoporosis or osteoarthritis by microindentation testing and electron probe microanalysis
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DOI：
10.1007/s00223-002-2080-8
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发表时间：
2003-07-01
影响因子：
4.2
通讯作者：
Aspden, RM
中科院分区：
文献类型：
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作者：
Coats, AM;Zioupos, P;Aspden, RM
骨关节炎(OA)患者的松质骨材料密度降低，似乎矿化不足。据推测，这将导致骨基质的机械硬度和强度降低。在本研究中，骨分别取自骨质疏松性髋部骨折(OP)术后取材的人股骨头，或因骨质疏松性髋关节置换(OA)行髋关节置换术的人股骨头，分别承受较高和较低负荷。采用微压痕法测量软骨下骨板不同深度松质骨的硬度。用电子探针显微分析(EPMA)测定了相邻微观位置的元素组成。总体而言，骨质疏松症患者的骨硬化值比骨质疏松症患者低7%。除女性骨质疏松症外，两种疾病患者下侧骨质均较上侧骨质坚硬。软骨下板以下无深度变化，性别差异无统计学意义。不同疾病组的骨骼成分没有发现差异，硬度和任何成分测量之间也没有发现相关性。虽然只是间接测量硬度，但硬度值的降低支持了这样一种假设，即骨性关节炎的弹性模数降低。
Cancellous bone from patients with osteoarthritis (OA) has a reduced material density and appears to be undermineralized. It is hypothesized that this will result in a reduction in the mechanical stiffness and strength of the bone matrix. In this study, bone was obtained from superior and inferior sites, subjected to relatively high and low loads, respectively, from human femoral heads retrieved after surgery for osteoporotic hip fracture (OP), or for hip arthroplasty due to OA. Microindentation testing was used to measure the hardness of cancellous bone at various depths from the subchondral bone plate. The elemental composition from immediately adjacent microscopic sites was determined using electron probe microanalysis (EPMA). Overall, OA bone was found to have hardness values that were 7% lower than those from OP bone. Bone from the inferior site was harder than that from the superior in both diseases except in female OP patients. There was no variation with depth below the subchondral plate and no difference between sexes. No difference was found in the composition of the bone from the different disease groups and no correlation was found between hardness and any of the composition measurements. Though only an indirect measurement of stiffness, the reduction in hardness values supports the hypothesis that OA bone has a reduced elastic modulus.