Non-high-density lipoprotein cholesterol level as a predictor of cardiovascular disease mortality
Non-high-density lipoprotein cholesterol level as a predictor of cardiovascular disease mortality
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DOI：
10.1001/archinte.161.11.1413
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发表时间：
2001-06-11
影响因子：
--
通讯作者：
Bush, TL
中科院分区：
文献类型：
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作者：
Cui, YD;Blumenthal, RS;Bush, TL
背景：非高密度脂蛋白胆固醇（non-HDL-C）包含所有已知的和潜在的致动脉粥样硬化的脂质颗粒。因此，非HDL-C水平可能与低密度脂蛋白胆固醇（LDL-C）一样是心血管疾病（CVD）风险的潜在预测因子。目的：确定非HDL-C水平是否可用于预测CVD死亡率，并比较非HDL-C和LDL-C水平的预测价值。数据来自脂质研究临床计划随访研究，这是一项死亡率研究，基线数据收集自1972年至1976年，死亡率确定至1995年。共有2406名男性和2056名女性，年龄在40至64岁，在进入观察了平均19年，CVD死亡作为主要结局measure.Results：共有234例CVD死亡的男性和113例CVD死亡的女性发生在随访期间。基线时HDL-C和非HDL-C水平是男女CVD死亡的显著和强预测因子，相比之下，LDL-C水平是男女CVD死亡的较弱预测因子。在男性中，非HDL-C和LDL-C水平差异0.78 mmol/L（30 mg/dL）分别对应于CVD风险增加19%和15%。在妇女中，0.78 mmol/L（30 mg/dL）的差异，在非HDL-C和LDL-C水平对应于增加11%和8%，分别心血管疾病的风险，Conclusions：非HDL-C水平是一个更好的预测心血管疾病的死亡率比LDL-C水平。非HDL-C水平的筛查可能有助于CVD风险评估。
Background: Non-high-density lipoprotein cholesterol (non-HDL-C) contains all known and potential atherogenic lipid particles. Therefore, non-HDL-C level may be as good a potential predictor of risk for cardiovascular disease (CVD) as low-density lipoprotein cholesterol (LDL-C).Objectives: To determine whether non-HDL-C level could be useful in predicting CVD mortality and to compare the predictive value of non-HDL-C and LDL-C levels.Methods: Data are from the Lipid Research Clinics Program Follow-up Study, a mortality study with baseline data gathered from 1972 through 1976, and mortality ascertained through 1995. A total of 2406 men and 2056 women aged 40 to 64 years at entry were observed for an average of 19 years, with CVD death as the main outcome measure.Results: A total of 234 CVD deaths in men and 113 CVD deaths in women occurred during follow-up. Levels of HDL-C and non-HDL-C at baseline were significant and strong predictors of CVD death in both sexes, In contrast, LDL-C level was a somewhat weaker predictor of CVD death in both. Differences of 0.78 mmol/L (30 mg/dL) in non-HDL-C and LDL-C levels corresponded to increases in CVD risk of 19% and 15%, respectively, in men. In women, differences of 0.78 mmol/L (30 mg/dL) in non-HDL-C and LDL-C levels corresponded to increases in CVD risk of 11% and 8%, respectively.Conclusions: Non-HDL-C level is a somewhat better predictor of CVD mortality than LDL-C level. Screening for non-HDL-C level may be useful for CVD risk assessment.