Naturally absorbed polyunsaturated fatty acids, lithium, and suicide-related behaviors: A case-controlled study
Naturally absorbed polyunsaturated fatty acids, lithium, and suicide-related behaviors: A case-controlled study
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DOI：
10.1016/j.jad.2018.08.006
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发表时间：
2018-12-01
影响因子：
6.6
通讯作者：
Yutaka, Matsuoka
中科院分区：
文献类型：
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作者：
Keiko, Kurosawa;Takeshi, Terao;Yutaka, Matsuoka
目的：以前的研究分别研究了omega-3、omega-6和锂对自杀相关行为的影响。本研究旨在全面研究自然吸收的EPA、DHA、花生四烯酸和锂对自杀未遂和故意自残的影响，并相互调整。方法：我们分析了197例患者的血浆EPA、DHA、花生四烯酸水平和血清锂水平，其中包括33例自杀未遂患者，18例故意自残患者，对照组146例。校正年龄、性别、EPA、DHA、花生四烯酸和对数转换锂水平的多变量logistic回归分析显示，（校正OR 0.972，95% CI 0.947-0.997，p = 0.031）和对数转换的锂水平（调整OR 0.156，95% CI 0.038-0.644，p = 0.01）以及与DHA水平的正相关性（调整OR 1.026，95% CI 1.010-1.043，p = 0.002）在自杀未遂患者中比对照组患者显著。该分析还表明，花生四烯酸水平的正相关（调整后OR 1.015，95%CI 1.005-1.025，p = 0.004）在故意自残患者中比对照组患者显著。局限性：局限性是患者数量相对较少，个体患者的人口统计学影响无法调整用于分析。目前的研究结果表明，作为自然吸收的营养素，较高的EPA和锂水平可能与较少的自杀企图有关，而较高的花生四烯酸水平可能与更多的故意自残有关。
Objective: Previous studies have investigated the effects of omega-3, omega-6 and lithium on suicide-related behaviors separately. This study was performed to comprehensively investigate the effects of naturally absorbed EPA, DHA, arachidonic acid and lithium in relation to suicide attempt and deliberate self-harm, with adjustment for each other.Methods: We analyzed plasma EPA, DHA, arachidonic acid levels and serum lithium levels of 197 patients including 33 patients with suicide attempts, 18 patients with deliberate self-harm, and 146 control patients.Results: Multivariate logistic regression analysis with adjustment for age, gender, EPA, DHA, arachidonic acid and log-transformed lithium levels revealed that the negative associations with EPA levels (adjusted OR 0.972, 95% CI 0.947-0.997, p = 0.031) and log-transformed lithium levels (adjusted OR 0.156, 95% CI 0.038-0.644, p = 0.01) and the positive association with DHA levels (adjusted OR 1.026, 95% CI 1.010-1.043, p = 0.002) were significant in patients with suicide attempts than in control patients. The analysis also demonstrated that the positive association with arachidonic acid levels (adjusted OR 1.015, 95% CI 1.005-1.025, p = 0.004) was significant in patients with deliberate self-harm than in control patients.Limitations: The limitations are relatively small number of patients and the effects of demographics of individual patients could not be adjusted for the analyses.Conclusions: The present findings suggest that, as naturally absorbed nutrients, higher EPA and lithium levels may be associated with less suicide attempt, and that higher arachidonic acid levels may be associated with more deliberate self-harm.