Synthesis, Characterization, and Magnetically Controlled Release Behavior of Novel Core-Shell Structural Magnetic Ibuprofen-Intercalated LDH Nanohybrids
Synthesis, Characterization, and Magnetically Controlled Release Behavior of Novel Core-Shell Structural Magnetic Ibuprofen-Intercalated LDH Nanohybrids
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DOI：
10.1021/jp901060v
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发表时间：
2009-06
影响因子：
3.7
通讯作者：
Hui Zhang;De-Hai Pan;X. Duan
中科院分区：
文献类型：
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作者：
Hui Zhang;De-Hai Pan;X. Duan
采用一步共沉淀法组装了LDH（层状双氢氧化物）基磁敏药物-无机纳米杂化物。采用XRD、TEM、XPS、VSM等方法，系统研究了磁性物质对布洛芬（IBU）插层Mg - Al - LDH磁性纳米杂化体微观结构和释放行为的影响，以及外加磁场（MF）和不外加磁场（MF）作用下的体外释放情况。结果表明，磁性纳米杂化材料具有明确的核壳结构，黑色磁芯表面包裹着灰色的IBU - LDH壳层，具有优异的磁灵敏度。与纯IBU - LDH的透明血小板相比，磁性纳米杂交体中的IBU - LDH涂层更像一层致密的层叠膜，完全覆盖在磁芯上，随着磁芯含量的增加，其粒径和厚度减小，这说明在无磁场的情况下，IBU - LDH涂层的释放率提高。而在1500 G的磁场下，由于磁芯含量的增加，释放速率大大降低。
LDH (layered double hydroxides)-based magnetic-sensitive drug−inorganic nanohybrids were assembled by a one-step co-precipitation method. The effect of a magnetic substance on the microstructure and drug release behavior of ibuprofen (IBU)-intercalated Mg−Al−LDH in magnetic nanohybrids was systematically studied via XRD, TEM, XPS, and VSM methods and in vitro release with and without an external magnetic field (MF). The results reveal a well-defined core−shell structure with a gray IBU−LDH shell coated onto the surface of a dark magnetic core and superior magnetic sensitivity of the magnetic nanohybrids. Compared with the clear platelets of the pure IBU−LDH, the IBU−LDH coatings in magnetic nanohybrids exhibit more like a compact stacking film fully covering the magnetic core and their particle sizes and thickness decrease with increasing core contents, explaining an enhanced release rate under no MF. While under a 1500 G MF, the release rate is greatly reduced with increasing core content due to the inst...