SCOLIOSIS INDUCED BY MEDULLARY DAMAGE - AN EXPERIMENTAL-STUDY IN RABBITS
SCOLIOSIS INDUCED BY MEDULLARY DAMAGE - AN EXPERIMENTAL-STUDY IN RABBITS
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DOI：
10.1097/00007632-198706000-00003
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发表时间：
1987-06-01
期刊：
影响因子：
3
通讯作者：
CANADELL, J
中科院分区：
文献类型：
--
作者：
BARRIOS, C;TUNON, MT;CANADELL, J
到目前为止，还没有通过直接损伤脊髓的不同区域来诱导脊柱侧凸的实验报告。在一系列的兔脊髓损伤，作者试图选择性地中断途径，介导本体感受输入。单侧损伤的背柱和后角的脊髓进行了三种不同的技术：凝固与激光，立体定位微凝固，纵向电凝。在32只手术兔中，17只发生脊柱侧凸，表现出明显的脊髓病理损伤。对10只脊髓损伤（脊柱侧凸和非脊柱侧凸）的家兔和12只对照组进行了电生理检查，包括肌电图和张力振动反射分析。这些数据表明，控制姿势紧张和随之而来的肌肉不平衡的感觉传入纤维的干扰，表示为凸侧肌肉活动减少。这项工作支持了这样的观点，即由脊髓损伤引起的本体感觉神经冲动的丧失可以诱发脊柱侧凸。
To date, there have been no reports of experiments designed to induce scoliosis by direct damage of different areas of the spinal cord. In a series of rabbits with medullary damage, the authors attempted selectively to interrupt the pathways that mediate proprioceptive input. Unilateral lesion of the dorsal column and posterior horn of the spinal cord was performed using three different techniques: coagulation with laser, stereotaxic microcoagulation, and longitudinal electrocoagulation. Of 32 operated rabbits, 17 developed scoliosis, exhibiting clear pathologic damage of the spinal cord. Electrophysiologic study, including EMG and analysis of the tonic-vibratory reflex, was performed on 10 rabbits with medullary damage (scoliotic and nonscoliotic) and 12 matched controls. The data suggest disturbance of the sensory afferences that control the postural tone and consequent muscular imbalance, expressed as reduced activity in the muscles of the convex side. This work supports the view that loss of proprioceptive neural impulses caused by medullary damage can induce scoliosis.