The Effects of Season of Birth on the Inflammatory Response to Psychological Stress in Hainan Island, China.
The Effects of Season of Birth on the Inflammatory Response to Psychological Stress in Hainan Island, China.
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DOI：
10.1371/journal.pone.0139602
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Watanabe C
中科院分区：
文献类型：
--
作者：
Yazawa A;Inoue Y;Stickley A;Li D;Du J;Watanabe C
出生季节（season of birth）是一个环境因素，它可能在表观遗传学上决定个体的生理机能。本研究调查了CRP在生活质量（QOL）（心理应激状态的代表）和C反应蛋白（CRP）浓度（即，炎症状态）。在干血斑样本中测量高灵敏度CRP浓度，同时使用世界卫生组织QOL问卷的简化版本来收集六个QOL领域的信息。按三个不同年龄组分层分析显示，CRP浓度、CRP、QOL之间存在显著相关性，最年轻组和最年长组的CRP和QOL之间存在相互作用。在年龄最大的组中，那些出生在旱季的人有更高的CRP浓度，生活质量更差，而在最年轻的组中，有更高的CRP浓度，生活质量更好。年人均大米产量，人口营养状况的代理人在出生的那一年，被发现预测CRP浓度只有在第二个最古老的组。这些发现表明，早期环境可能会影响成年后对心理压力的免疫反应，其影响可能因人们出生的时间而异。
Season of birth (SOB) has been investigated as one of the environmental factors that might epigenetically determine the physiology of individuals. This study investigated the role of SOB in the association between Quality of Life (QOL), a proxy of psychological stress status, and C-reactive protein (CRP) concentration (i.e., inflammatory status) among 1,085 adults (aged 20–57 years old) in Hainan Island, China. High sensitivity CRP concentration was measured in dried blood spot samples, while the abbreviated version of the World Health Organization’s QOL questionnaire was used to gather information on six QOL domains. Analysis stratified by three historically distinct age groups revealed a significant association between CRP concentration, SOB, QOL and an interaction between SOB and QOL among the youngest and oldest groups. In the oldest group, those born in the dry season had a higher CRP concentration with worse QOL whereas in the youngest group, there was a higher CRP concentration with better QOL. Annual per capita rice production, a proxy of population nutritional status in the year of birth, was found to predict CRP concentration only among the second oldest group. These findings suggest that the early environment might affect the immune response to psychological stress in adulthood and that its effect may differ by the time period in which people were born.