The interaction of chronic restraint stress and voluntary alcohol intake: Effects on spatial memory in male rats
The interaction of chronic restraint stress and voluntary alcohol intake: Effects on spatial memory in male rats
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DOI：
10.1016/j.alcohol.2011.12.005
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发表时间：
2012-08-01
期刊：
影响因子：
2.3
通讯作者：
Luine, Victoria N.
中科院分区：
文献类型：
--
作者：
Gomez, Juan L.;Lewis, Michael J.;Luine, Victoria N.
饮酒和暴露于压力生活事件会激活类似的神经通路，从而导致一些类似的生理和行为影响。接受治疗的酗酒者声称，生活压力是持续饮酒或复发的主要原因。然而，很少有研究调查压力和酒精对认知行为的交互影响。在空间记忆测试、物体放置（OP）任务中检查了束缚压力、酒精以及压力与酒精结合的影响。此外，还测量了摄入量，以确定压力是否会改变一般的饮酒量。雄性 Sprague-Dawley 大鼠被分配到四种条件之一：无酒精/无应激控制 (CON)、仅应激 (STR)、仅酒精 (ALC) 和 STR + 酒精 (STR + ALC)。每次约束应力回合后，STR + ALC 组和 ALC 组使用两瓶选择有限进入范例获得 8% 酒精 1 小时。正如预测的那样，STR + ALC 组的饮酒量显着增加，而 ALC 组在 10 天的治疗期间持续饮酒。在 OP 任务中，STR 和 ALC 组在机会水平上表现良好，而 CON 和 STR + ALC 组在新位置和旧位置的对象之间有显着区分。这些数据表明，压力会增加酒精摄入量，而酒精摄入量与减少压力引起的空间记忆损伤有关。这些数据对酗酒及其治疗的发展具有重要意义。 (C) 2012 Elsevier Inc. 保留所有权利。
Alcohol consumption and exposure to stressful life events activate similar neural pathways and thus result in several comparable physiological and behavioral effects. Alcoholics in treatment claim that life stressors are the leading cause of continued drinking or relapse. However, few studies have investigated the interactive effects of stress and alcohol on cognitive behavior. The effects of restraint stress, alcohol, and stress in combination with alcohol were examined on a spatial memory test, the object placement (OP) task. In addition, intake levels were measured to determine if stress altered general consumption of alcohol. Male Sprague-Dawley rats were assigned to one of four conditions: no alcohol/no stress control (CON), stress alone (STR), alcohol alone (ALC), and STR + alcohol (STR + ALC). Following each restraint stress bout, the STR + ALC and the ALC groups were given access to 8% alcohol for 1 h using the two-bottle choice limited access paradigm. As predicted, the STR + ALC group significantly increased alcohol consumption, while the ALC group had consistent drinking over the 10-day treatment. On the OP task, STR and ALC groups performed at chance levels, whereas the CON and STR + ALC groups significantly discriminated between objects in the new and old locations. These data show that stress increases alcohol intake and the intake of alcohol is associated with reduction of the stress-induced impairment of spatial memory. The data have important implications for the development of alcohol abuse and its treatment. (C) 2012 Elsevier Inc. All rights reserved.