Tumor-infiltrating lymphocytes predict cutaneous melanoma survival
Tumor-infiltrating lymphocytes predict cutaneous melanoma survival
复制标题
DOI：
10.1097/cmr.0000000000000164
复制
发表时间：
2015-08-01
影响因子：
2.2
通讯作者：
Michelozzi, Paola
中科院分区：
文献类型：
--
作者：
Fortes, Cristina;Mastroeni, Simona;Michelozzi, Paola
了解不同亚组黑色素瘤患者存活率的差异可能有助于选择治疗类型。肿瘤浸润性淋巴细胞(TILs)被认为是宿主对肿瘤免疫反应的一种表现，但TILs在黑色素瘤死亡率中的作用存在争议。这项研究的目的是调查黑色素瘤死亡率的独立预后因素。我们对1998年1月至2008年12月间确诊为原发性皮肤黑色素瘤的4133名来自同一地理区域(拉齐奥)的黑色素瘤患者进行了为期10年的队列研究。生存概率用Kaplan-Meier方法估计，预后因素用多因素分析(Cox比例风险模型)估计。随着Breslow厚度的增加，黑色素瘤的10年生存率下降(P-趋势
Understanding differences in survival across distinct subgroups of melanoma patients may help with the choice of types of therapy. Tumor-infiltrating lymphocytes (TILs) are considered a manifestation of the host immune response to tumor, but the role of TILs in melanoma mortality is controversial. The aim of this study was to investigate independent prognostic factors for melanoma mortality. We carried out a 10-year cohort study on 4133 melanoma patients from the same geographic area (Lazio) with primary cutaneous melanoma diagnosed between January 1998 and December 2008. The probability of survival was estimated using Kaplan-Meier methods and prognostic factors were evaluated by multivariate analysis (Cox proportional hazards model). The 10-year survival rate for melanoma decreased with increasing Breslow thickness (P-for trend