Association of leisure-time physical activity with total and cause-specific mortality: a pooled analysis of nearly a half million adults in the Asia Cohort Consortium
Association of leisure-time physical activity with total and cause-specific mortality: a pooled analysis of nearly a half million adults in the Asia Cohort Consortium
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DOI：
10.1093/ije/dyy024
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发表时间：
2018-06-01
影响因子：
7.7
通讯作者：
Zheng, Wei
中科院分区：
文献类型：
--
作者：
Liu, Ying;Shu, Xiao-Ou;Zheng, Wei
背景：以前大多数评估休闲时间体育活动(LTPA)和死亡风险之间关系的研究都是在一般健康的欧洲血统的个人中进行的。我们调查了东亚人群中LTPA与全原因和特定原因死亡率的关系，包括健康个体和既有慢性病患者，这方面的特征还不太清楚。方法：我们对包括亚洲队列联盟在内的9个前瞻性队列中招募的467 729名东亚个体进行了汇总分析。在调整了年龄、性别、教育程度、婚姻和吸烟状况后，使用COX比例风险回归得出与LTPA相关的危险比(HR)和95%可信区间(CI)。结果：在平均13.6年的随访期内，确认了65858例死亡。与每周不服药或服药时间少于1小时的受试者相比，受试者服药剂量与全因死亡率和病因死亡率呈负相关(P为Trend<；0.001)。在死于心血管疾病和癌症以外的其他原因时，反向关联的强度更强。在患有严重且往往危及生命的疾病：癌症、中风或冠心病[风险比(HR)=0.81，高LTPA与低LTPA的95%CI=0.73-0.89]以及患有其他慢性病如糖尿病或高血压(HR=0.86，95%CI=0.80-0.93)的患者中，LTPA与总死亡率呈负相关。没有明确的性别、体重指数或吸烟状况的影响。结论：在中老年亚洲人中，定期参加LTPA与降低死亡率有关，而不考虑既往的健康状况。
Background: Most previous studies evaluating the association between leisure-time physical activity (LTPA) and risk of death were conducted among generally healthy individuals of European ancestry. We investigated the association of LTPA with all-cause and cause-specific mortality among East Asian populations, including healthy individuals and those with existing chronic diseases, which has been less well characterized.Methods: We performed pooled analyses among 467 729 East Asian individuals recruited in nine prospective cohorts included in the Asia Cohort Consortium. Cox proportional hazards regressions were used to derive hazard ratios (HRs) and 95% confidence intervals (CIs) associated with LTPA after adjusting for age, sex, education and marital and smoking status.Results: During a mean follow-up period of 13.6 years, 65 858 deaths were identified. Compared with those who reported no or less than 1 h of LTPA per week, an inverse association was observed between the amount of LTPA and all-cause and cause-specific mortality (P for trend < 0.001). The strength of the inverse association was stronger for death due to cardiovascular diseases and causes other than cancer deaths. An inverse association of LTPA with total mortality was observed among individuals with a severe and often life-threatening disease: cancer, stroke or coronary heart disease [hazard ratio (HR) = 0.81, 95% CI = 0.73-0.89 for high vs low LTPA) and those with other chronic diseases such as diabetes or hypertension (HR = 0.86, 95% CI = 0.80-0.93 for high vs low LTPA). No clear modifying effects by sex, body mass index or smoking status were identified.Conclusions: Regular participation in LTPA is associated with reduced mortality in middle-aged and elder Asians regardless pre-existing health conditions.