Influence of carbon nanotubes and graphene nanosheets on photothermal effect of hydroxyapatite.
Influence of carbon nanotubes and graphene nanosheets on photothermal effect of hydroxyapatite.
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DOI：
10.1016/j.jcis.2016.07.078
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发表时间：
2016-12-15
影响因子：
9.9
通讯作者：
Oki AR
中科院分区：
文献类型：
--
作者：
Neelgund GM;Oki AR
在此，我们提出了一个成功的策略，有效地提高光热效率的羟基磷灰石（HAP）的共轭与碳纳米管（CNT）和石墨烯纳米片（GR）。由于与人体的良好生物相容性及其无毒性，在光热治疗（PTT）中实施基于HAP的纳米材料提供了目前使用的PTE试剂不可替代的益处。因此，在这份报告中，它已被实验利用，HAP的光热效应（PTE）有显着改善其组装与CNT和GR。它被发现，用于共轭与HAP的碳纳米材料的类型影响其PTE在这样一种方式，即光热效率GR-HAP是高于CNTs-COOH-HAP暴露于980 nm近红外（NIR）激光。发现CNTs-COOH-HAP和GR-HAP的水性分散体在NIR辐射照射7分钟后达到的温度高于50 ° C，这超出了癌细胞的温度耐受性。因此，CNTs-COOH-HAP和GR-HAP显示的温度升高足以诱导肿瘤或癌细胞的死亡。总体而言，这种以HAP与CNT和GR的方式的方法为未来无毒PTE剂的开发提供了巨大的潜力。
Herein we present a successful strategy for efficient enhancement of photothermal efficiency of hydroxyapatite (HAP) by its conjugation with carbon nanotubes (CNTs) and graphene nanosheets (GR). Owing to excellent biocompatibility with human body and its non-toxicity, implementation of HAP based nanomaterials in photothermal therapy (PTT) provides non-replaceable benefits over currently using PTE agents. Therefore, in this report, it has been experimentally exploited that the photothermal effect (PTE) of HAP has significantly improved by its assembly with CNTs and GR. It is found that the type of carbon nanomaterial used to conjugate with HAP has influenced on its PTE in such a way that the photothermal efficiency of GR-HAP was higher than CNTs-COOH-HAP under exposure to 980 nm near-infrared (NIR) laser. The temperature attained by aqueous dispersions of both CNTs-COOH-HAP and GR-HAP after illuminating to NIR radiations for 7 min was found to be above 50 ° C, which is beyond the temperature tolerance of cancer cells. So that the rise in temperature shown by both CNTs-COOH-HAP and GR-HAP is enough to induce the death of tumoral or cancerous cells. Overall, this approach in modality of HAP with CNTs and GR provide a great potential for development of future nontoxic PTE agents.