Epidemiology of Inflammatory Bowel Disease in India: The Great Shift East.
Epidemiology of Inflammatory Bowel Disease in India: The Great Shift East.
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DOI：
10.1159/000465522
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发表时间：
2017-11-01
影响因子：
--
通讯作者：
Ahuja, Vineet
中科院分区：
文献类型：
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作者：
Kedia, Saurabh;Ahuja, Vineet
背景技术背景：炎症性肠病（IBD），曾经被认为是一种西方疾病，越来越多地报告来自印度和其他亚洲国家。本综述总结了印度IBD的流行病学和疾病特征，并参考其他亚洲国家和西方国家。SUMMARY：预计印度将成为地球仪中IBD疾病负担最高的国家之一。印度IBD患者的总体遗传风险和微生物特征与西方患者相似，这一点通过第二代印度移民中IBD的相似发病率以及印度研究中肠道微生物群结构和功能组分的匹配扰动来证明。卫生假说的概念仍然存在争议，印度的研究显示了相互矛盾的结果。印度IBD患者的疾病特征、长期结局（包括结直肠癌风险）以及妊娠对IBD的影响（反之亦然）通常相似，差异不大。与西方国家的患者不同，印度患者很少有阳性家族史。关键信息：随着IBD发病率的激增，印度疾病模式正在经历流行病学转变阶段。IBD的流行病学和疾病特征反映了在西方观察到的模式。
BACKGROUND: Inflammatory bowel disease (IBD), once considered to be a Western disease, is increasingly being reported from India and other Asian countries. The present review summarizes epidemiology and disease characteristics of IBD in India with reference to other Asian countries and the West.SUMMARY: India is projected to have one of the highest disease burden of IBD across the globe. The overall genetic risk and microbial signature in Indian IBD patients are similar to those of patients in the West as demonstrated by the similar incidence of IBD in second-generation Indian immigrants and matching perturbations in the structural and functional component of gut microbiota in Indian studies. The concept of the hygiene hypothesis continues to remain controversial with Indian studies demonstrating contradictory findings. The disease characteristics, long-term outcomes including the risk of colorectal cancer, and the effect of pregnancy on IBD and vice versa in Indian patients with IBD are in general similar with few differences. Unlike patients in the West, very few Indian patients have a positive family history.KEY MESSAGE: The Indian disease pattern is going through a phase of epidemiological transition with a surge in the incidence of IBD. The epidemiology and disease characteristics of IBD mirror the patterns observed in the West.