Brain activity during bladder filling and pelvic floor muscle contractions: A study using functional magnetic resonance imaging and synchronous urodynamics
Brain activity during bladder filling and pelvic floor muscle contractions: A study using functional magnetic resonance imaging and synchronous urodynamics
复制标题
DOI：
10.1111/iju.12211
复制
发表时间：
2014-02-01
影响因子：
2.6
通讯作者：
Zvara, Peter
中科院分区：
文献类型：
--
作者：
Krhut, Jan;Holy, Petr;Zvara, Peter
目的：映射的大脑活动在膀胱充盈功能磁共振成像使用一个完善的扫描协议，包括同步尿动力学和盆底肌肉contractions.Methods：共23名健康女性志愿者（年龄20-68岁）被纳入。参与者被要求收缩他们的骨盆底肌肉。随后进行尿动力学检查，包括重复充盈周期。使用3 T磁共振系统通过功能性磁共振成像测量脑活动。对大脑活动的测量包括120次盆底收缩期间的功能扫描和210次膀胱充盈期间的扫描。每个功能性磁共振成像扫描覆盖大脑35个切片。统计分析采用一般线性模型和独立成分分析。激活区域可视化使用组statistics.Results：在盆底肌肉收缩过程中观察到以下主要集群的激活：额叶内侧表面（主运动区），双侧;补充运动区，双侧;和左中央前回。在膀胱充盈期间，激活检测到额叶下边缘的额叶扣带回，左侧顶回上级，左侧中央区，右颞叶，脑干和丘脑与皮质下灰质nucleus.Conclusions：我们的工作扩展了现有的功能磁共振成像研究下尿路的神经控制协议。目前的结果与现有文献一致，并同意目前假设的下尿路神经控制的功能模型。
Objectives: To map the brain activity during bladder filling by functional magnetic resonance imaging using a refined scanning protocol including synchronous urodynamics and pelvic floor muscle contractions.Methods: A total of 23 healthy female volunteers (age 20-68 years) were enrolled. Participants were asked to contract their pelvic floor muscles. This was followed by a urodynamic examination consisting of repeated filling cycles. Brain activity was measured by functional magnetic resonance imaging using a 3T magnetic resonance system. Measurements of brain activity consisted of 120 functional scans during pelvic floor contractions and 210 scans during bladder filling. Each functional magnetic resonance imaging scan covered the brain with 35 slices. Statistical analyses used the general linear model and independent component analysis. Areas of activation were visualized using group statistics.Results: The following main clusters of activation were observed during pelvic floor muscle contractions: medial surface of the frontal lobe (primary motor area), bilaterally; supplementary motor area, bilaterally; and left gyrus precentralis. During bladder filling, activation was detected in the inferior frontal lobe bordering the frontal cingulum, left gyrus parietalis superior, left central area, right insula, brainstem and thalamus with subcortical gray matter nuclei.Conclusions: Our work extends an existing functional magnetic resonance imaging protocol for researching the neural control of the lower urinary tract. The present results are consistent with the available literature and agree with the present hypothetical functional model of lower urinary tract neural control.