Expression of aminopeptidase N/CD13 in human ovarian cancers
Expression of aminopeptidase N/CD13 in human ovarian cancers
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DOI：
10.1111/j.1525-1438.2006.00657.x
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发表时间：
2006-09-01
影响因子：
4.8
通讯作者：
Lage, H.
中科院分区：
文献类型：
--
作者：
Surowiak, P.;Drags, M.;Lage, H.
氨肽酶N/CD 13（EC 3.4.11.2）被认为在癌细胞侵袭中起作用，并且其活性可以使用特异性抑制剂来抑制。CD 13抑制剂引起CD 13阳性癌细胞的凋亡。然而，CD 13的表达还没有被描述在卵巢癌标本。因此，在本研究中，CD 13的表达及其意义的卵巢癌样本进行了检查。对73份肿瘤样本（43份来自初次剖腹术[PL]，30份来自二次细胞减灭术[SCR]）的切片进行分析。使用抗CD 13的单克隆抗体，在所研究的肿瘤的石蜡切片上进行免疫组织化学反应。分析表明一方面CD 13的表达与患者的临床变量和病理变量之间没有关系。与来自SCR的样品相比，在PL中获得的样品中CD 13的表达被证明显著更显著（P < 0.001）。因此，数据表明，卵巢癌的潜在治疗与CD 13抑制剂应进行化疗前或平行于首次失效化疗。
Aminopeptidase N/CD13 (EC 3.4.11.2) is suggested to play a role in cancer cells invasion, and its activity can be inhibited using specific inhibitors. CD13 inhibitors evoke apoptosis of CD13-positive cancer cells. However, expression of CD13 has not been described in specimens obtained from ovarian carcinomas. Thus, in the present study, the expression of CD13 and its significance was examined in samples of ovarian cancers. The analyses were performed on sections originating from 73 tumor samples (43 from primary laparotomies [PL] and 30 from secondary cytoreductions [SCRs]). Immunohistochemical reactions were performed on paraffin sections of studied tumors, using monoclonal antibodies against CD13. The analysis demonstrated no relationships between the expression of CD13 on one hand and clinical variables and pathologic variables of the patients on the other hand. Expression of CD13 was demonstrated to be significantly more pronounced in samples obtained in PLs as compared to samples from SCRs (P < 0.001). Thus, the data indicate that a potential treatment of ovarian carcinoma with CD13 inhibitors should be performed before chemotherapy or in parallel to first-lapse chemotherapy.