The heritability of hedonic capacity and perceived stress: a twin study evaluation of candidate depressive phenotypes
The heritability of hedonic capacity and perceived stress: a twin study evaluation of candidate depressive phenotypes
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DOI：
10.1017/s0033291708003619
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发表时间：
2009-02-01
影响因子：
6.9
通讯作者：
Pizzagalli, D. A.
中科院分区：
文献类型：
--
作者：
Bogdan, R.;Pizzagalli, D. A.
背景。快感缺乏和压力敏感性已被确定为有希望的抑郁表型。研究表明，压力引起的快感缺乏可能是压力与抑郁之间关联的潜在机制。目前的概念验证研究评估了享乐能力和压力感知是否可遗传，以及它们的遗传和环境贡献是否共享。方法。 20 对同卵 (MZ) 和 15 对异卵 (DZ) 双胞胎完成了一项概率奖励任务，该任务提供了享乐能力（奖励反应性）的客观行为测量，并完成了包括感知压力量表 (PSS) 在内的几份调查问卷。使用双变量 Cholesky 模型来研究（1）抑郁症状和享乐能力之间的协变，（2）抑郁症状和感知压力，以及（3）感知压力和享乐能力之间的协变是否由共享或残留的遗传和环境因素引起。结果。加性遗传 (A) 和个体特定环境 (E) 因素分别导致享乐能力差异的 46% 和 54%。对于感知压力，A 因素和 E 因素分别占方差的 44% 和 56%。抑郁症与享乐能力之间的遗传相关性中等（r（a）= 0.29），而抑郁症与压力感知之间的相关性较大（r（a）= 0.67）。享乐能力和压力感知之间的遗传和环境相关性很大（r（a）= 0.72和r（e）= -0.43）。结论。本研究为使用双胞胎方法研究基于实验室的快感缺失表型的遗传贡献提供了初步可行性。尽管这些初步发现表明享乐能力和感知压力是可遗传的，并且具有大量共同的附加遗传贡献，但仍需要在更大的样本中进行复制。
Background. Anhedonia and stress sensitivity have been identified as promising depressive phenotypes. Research suggests that stress-induced anhedonia is a possible mechanism underlying the association between stress and depression. The present proof-of-concept study assessed whether hedonic capacity and stress perception are heritable and whether their genetic and environmental contributions are shared.Method. Twenty monozygotic (MZ) and 15 dizygotic (DZ) twin pairs completed a probabilistic reward task that provides an objective behavioral measure of hedonic capacity (reward responsiveness) and completed several questionnaires including the Perceived Stress Scale (PSS). Bivariate Cholesky models were used to investigate whether covariation between (1) depressive symptoms and hedonic capacity, (2) depressive symptoms and perceived stress, and (3) perceived stress and hedonic capacity resulted from shared or residual genetic and environmental factors.Results. Additive genetic (A) and individual-specific environment (E) factors contributed to 46% and 54% of the variance in hedonic capacity, respectively. For perceived stress, 44% and 56%, of the variance was accounted for by A and E factors, respectively. The genetic correlation between depression and hedonic capacity was moderate (r(a)=0.29), whereas the correlation between depression and stress perception was large (r(a)=0.67). Genetic and environmental correlations between hedonic capacity and stress perception were large (r(a)=0.72 and r(e)= -0.43).Conclusions. The present study provides initial feasibility for using a twin approach to investigate genetic contributions of a laboratory-based anhedonic phenotype. Although these preliminary findings indicate that hedonic capacity and perceived stress are heritable, with substantial shared additive genetic contributions, replications in larger samples will be needed.