A receptor/cytoskeletal movement triggered by costimulation during T cell activation
A receptor/cytoskeletal movement triggered by costimulation during T cell activation
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DOI：
10.1126/science.282.5397.2266
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发表时间：
1998-12-18
期刊：
影响因子：
56.9
通讯作者：
Davis, MM
中科院分区：
文献类型：
--
作者：
Wülfing, C;Davis, MM
在T细胞活化过程中，共刺激分子的参与通常对有效免疫反应的发展至关重要，但实现这一目标的机制尚不清楚。在这里，它显示了附着在T细胞表面的小珠在T细胞激活开始后不久就向界面转移。这种运动似乎依赖于肌球蛋白运动蛋白，并需要主要的共刺激受体对B7-CD28和ICAM-1-LFA-1的参与。这表明共刺激受体的参与触发了分子在T细胞和抗原呈递细胞界面的活跃积累，从而增加了T细胞信号传导的总体幅度和持续时间。
During T cell activation, the engagement of costimulatory molecules is often crucial to the development of an effective immune response, but the mechanism by which this is achieved is not known. Here, it is shown that beads attached to the surface of a T cell translocate toward the interface shortly after the start of T cell activation. This movement appears to depend on myosin motor proteins and requires the engagement of the major costimulatory receptor pairs, B7-CD28 and ICAM-1-LFA-1. This suggests that the engagement of costimulatory receptors triggers an active accumulation of molecules at the interface of the T cell and the antigen-presenting cell, which then increases the overall amplitude and duration of T cell signaling.