The epidemiology of human hookworm infections in the southern region of Mali
The epidemiology of human hookworm infections in the southern region of Mali
复制标题
DOI：
10.1046/j.1365-3156.2000.00553.x
复制
发表时间：
2000-05-01
影响因子：
3.3
通讯作者：
Vercruysse, J
中科院分区：
文献类型：
--
作者：
Behnke, JM;De Clercq, D;Vercruysse, J
相隔三年（1994年12月和1998年1月）在马尔省Sikasso地区的一个村庄进行的两次钩虫（美洲钩虫）感染调查显示，总感染率分别为68.7%和53%。在这两年中，感染的流行程度和数量在性别之间存在高度显著差异，男性受试者比女性携带更重的感染。感染率和感染率都随着年龄的增长而增加，尽管1998年性别和年龄之间存在强烈的相互作用，原因是16-20岁女性的卵子数量减少，而男性的卵子数量继续增加，随后老年男性（大于或等于61岁）的数量减少，而女性的数量也随之增加。在控制了年龄、性别及其相互作用的影响后，在1994年和1998年接受检查的个体（n = 134）的粪卵数量之间发现了高度显著的正相关，表明易受感染。这种关系在7-79岁的4个年龄组中都保持显著。一些家族化合物的成员携带的感染比预期的要严重，而另一些家族化合物的感染较少，这表明与化合物有关的钩虫感染聚集性。鞋的使用随着年龄的增长而增加，但鞋的使用程度与钩虫感染的数量之间没有显著的关系。视力随着年龄的增长而恶化，视力受损在社区的老年人中尤为突出，这是盘尾丝虫病在该地区广泛流行的遗留问题。虽然眼睛部分受损的男性的感染率低于其年龄的预期，但在视力质量和钩虫感染之间没有发现总体上显著的关系。本文讨论了这些结果与钩虫流行病学的关系，特别是与马里钩虫流行病学的关系。
Two surveys of hookworm (Necator americanus) infections, conducted three years apart (December 1994 and January 1998) in a village in the Sikasso region of Mall, revealed that overall prevalence of infection was 68.7% and 53%, respectively. In both years there was a highly significant difference between the sexes in the prevalence and abundance of infection, with male subjects carrying heavier infections than females. Both prevalence and abundance of infection increased with age, although in 1998 there was a strong interaction between sex and age, arising from the declining egg counts among 16-20-year-old females and the continuing increase among males, reinforced by the subsequent reduction among the older males (greater than or equal to 61 years) and concomitant increase among females. After controlling for the effects of age, sex and their interaction, a highly significant positive relationship was detected between faecal egg counts of individuals who were examined in both 1994 and 1998 (n = 134), indicating predisposition to infection. This relationship remained significant in each of 4 age classes spanning 7-79 years. The members of some family compounds were shown to carry heavier infections than expected whilst others were less infected, suggesting compound-related clustering of hookworm infections. The use of footwear increased with age but there was no significant relationship between the extent of use of footwear and the abundance of hookworm infection. Eyesight deteriorated with age and impaired vision was particularly prominent among the older sectors of the community, a legacy from the time when onchocerciasis was widely prevalent in the region, Although men with partially damaged eyes carried lower infections than expected for their age, no overall significant relationship was found between quality of Vision and hookworm infections. These results are discussed in relation to hookworm epidemiology in general and in Mali in particular.