Effects of grape seed proanthocyanidin extracts on peripheral nerves in streptozocin-induced diabetic rats
Effects of grape seed proanthocyanidin extracts on peripheral nerves in streptozocin-induced diabetic rats
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DOI：
10.3177/jnsv.54.321
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发表时间：
2008-08-01
影响因子：
1.6
通讯作者：
Lu, Mei
中科院分区：
文献类型：
--
作者：
Cu, Xiao-pei;Li, Bao-ying;Lu, Mei
糖尿病周围神经病变(DPN)是糖尿病最常见的慢性并发症之一。本研究的目的是阐明葡萄籽原花青素提取物(GSPE)是否是治疗DPN的药物。本研究采用链脲佐菌素(STZ)诱导糖尿病大鼠模型。给糖尿病大鼠灌胃GSPE(250 mg/kg体重/d)24 wk。测定大鼠运动神经传导速度(MNCV)和机械性痛敏反应。空腹血糖。糖化血红蛋白。测定糖基化终产物(AGEs)、组织丙二醛(MDA)和超氧化物歧化酶(SOD)。在光镜和电子显微镜下观察神经超微结构的变化。GSPE能显著提高糖尿病大鼠的MNCV、机械性痛觉过敏和超氧化物歧化酶(P
Diabetic peripheral neuropathy (DPN) is one of the most common diabetic chronic complications. The aim of this study was to clarify whether grape seed proanthocy-anidins extracts (GSPE) are therapeutic agents against DPN. In this study we used streptozocin (STZ) to induce diabetic rats. GSPEs (250 mg/kg body weight/d) were administrated to diabetic rats for 24 wk. Motor nerve conductive velocity (MNCV) and mechanical hyperalgesia were determined in the rats. Serum glucose. glycated hemoglobin. advanced glycation end products (AGEs), and tissue malondialdehyde (MDA) and superoxide dismutase (SOD) were determined. Light and electron microscopy were used to observe the changes of nerval ultrastructure.GSPE significantly increased the MNCV mechanical hyperalgesia and SOD of diabetic rats (p