Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids: negative interference of activated glucocorticoid receptor with transcription factors
Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids: negative interference of activated glucocorticoid receptor with transcription factors
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DOI：
10.1016/s0165-5728(00)00297-6
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发表时间：
2000-09-01
影响因子：
3.3
通讯作者：
Haegeman, G
中科院分区：
文献类型：
--
作者：
De Bosscher, K;Vanden Berghe, W;Haegeman, G
糖皮质激素是应用最广泛的抗炎和免疫调节剂，其作用机制主要是基于干扰转录因子如核因子κ B（NF-κ B B）和激活蛋白-1（AP-1）的活性。由于存在许多相互矛盾的假说，糖皮质激素抑制基因的确切分子机制是一个有争议的问题。我们讨论了文献中报道的三种主要范式，即抑制剂κ B-α（I κ B-α）上调模型，蛋白质-蛋白质相互作用模型和竞争模型。(C)2000 Elsevier Science BN。All rights reserved.
Glucocorticoids are the most widely used anti-inflammatory and immunomodulatory agents, whose mechanism of action is based mainly on interference with the activity of transcription Factors, such us nuclear factor kappa B (NF-kappa B) and activator protein-1 (AP-1). The precise molecular mechanisms of gene repression by glucocorticoids are a controversial matter, due to the existence of many conflicting hypotheses. We discuss the three main paradigms reported in the literature, namely the inhibitor kappa B-alpha (I kappa B-alpha) upregulatory model, the protein-protein interaction model and the competition model. (C) 2000 Elsevier Science BN. All rights reserved.