A non-invasive method for focusing ultrasound through the human skull
A non-invasive method for focusing ultrasound through the human skull
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DOI：
10.1088/0031-9155/47/8/301
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发表时间：
2002-04-21
影响因子：
3.5
通讯作者：
Hynynen, K
中科院分区：
文献类型：
--
作者：
Clement, GT;Hynynen, K
描述并验证了一种通过人颅骨聚焦超声的技术。该方法是基于一个分层的波矢量频域模型，它传播超声波从半球形换能器通过头骨使用输入从头部的CT扫描。该算法计算每个换能器元件的驱动相位，以使预期焦点处的信号最大化。使用0.74 MHz，320个元件阵列在10个离体人类头骨上测试这种方法。将立体定位参考框架固定到颅骨，以便提供CT图像和换能器之间的准确配准。用放置在颅骨内的水听器评估焦点质量。在每次试验中，相位校正算法成功地将颅骨内的焦点恢复到距预期焦点1 mm以内的位置。结果表明，使用该方法进行完全无创超声脑外科手术和治疗的可行性。
A technique for focusing ultrasound through the human skull is described and verified. The approach is based on a layered wavevector-frequency domain model, which propagates ultrasound from a hemisphere-shaped transducer through the skull using input from CT scans of the head. The algorithm calculates the driving phase of each transducer element in order to maximize the signal at the intended focus. This approach is tested on ten ex vivo human skulls using a 0.74 MHz, 320-element array. A stereotaxic reference frame is affixed to the skulls in order to provide accurate registration between the CT images and the transducer. The focal quality is assessed with a hydrophone placed inside the skull. In each trial the phase correction algorithm successfully restored the focus inside the skull at a location within I mm from the intended focal point. The results demonstrate the feasibility of using the method for completely non-invasive ultrasound brain surgery and therapy.