Mechanical injury and repair of cells
Mechanical injury and repair of cells
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DOI：
10.1097/01.ccm.0000081432.72812.16
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发表时间：
2003-08-01
影响因子：
8.8
通讯作者：
McNeil, PL
中科院分区：
文献类型：
--
作者：
Miyake, K;McNeil, PL
客观的。简要回顾细胞质膜破坏（撕裂的细胞表面）和修复领域。要点：质膜破坏是生理条件下、创伤后、某些肌营养不良症以及某些形式的临床干预期间细胞损伤的常见形式。快速修复损伤对于细胞生存至关重要，涉及复杂而活跃的细胞反应，包括膜融合和细胞骨架激活。心肌和骨骼肌等组织通过肥大来适应破坏性损伤。细胞通过提高其重新密封反应的效率来适应。结论：质膜破坏是健康和疾病中的重要细胞事件。目前，破坏修复机制在细胞水平上已得到很好的了解，但在分子水平上仍有许多东西有待了解。细胞和组织水平对破坏的适应性反应要么阻止其进一步发生，要么促进未来的修复。如果利用这些积累的知识，可以开发出可以增强修复或适应性反应的化学制剂，则可能会产生治疗有用的药物。
Objective. To concisely review the field of cell plasma membrane disruption (torn cell surface) and repair.Main Points: Plasma membrane disruption is a common form of cell injury under physiologic conditions, after trauma, in certain muscular dystrophies, and during certain forms of clinical intervention. Rapid repair of a disruption is essential to cell survival and involves a complex and active cell response that includes membrane fusion and cytoskeletal activation. Tissues, such as cardiac and skeletal muscle, adapt to a disruption injury by hypertrophying. Cells adapt by increasing the efficiency of their resealing response.Conclusion: Plasma membrane disruption is an important cellular event in both health and disease. The disruption repair mechanism is now well understood at the cellular level, but much remains to be learned at the molecular level. Cell and tissue level adaptational responses to the disruption either prevent its further occurrence or facilitate future repairs. Therapeutically useful drugs might result if, using this accumulating knowledge, chemical agents can be developed that can enhance repair or adaptive responses.