The Association of Prenatal Exposure to Perfluorinated Chemicals with Glucocorticoid and Androgenic Hormones in Cord Blood Samples: The Hokkaido Study.
The Association of Prenatal Exposure to Perfluorinated Chemicals with Glucocorticoid and Androgenic Hormones in Cord Blood Samples: The Hokkaido Study.
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DOI：
10.1289/ehp142
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发表时间：
2017-01
影响因子：
10.4
通讯作者：
Kishi R
中科院分区：
文献类型：
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作者：
Goudarzi H;Araki A;Itoh S;Sasaki S;Miyashita C;Mitsui T;Nakazawa H;Nonomura K;Kishi R
全氟化学品（PFCs）破坏胆固醇稳态。所有的类固醇激素都来源于胆固醇，类固醇激素如糖皮质激素和雄激素介导几种重要的生理功能。然而，在子宫内的全氟化碳暴露对这些类固醇激素的体内平衡的影响还没有很好地了解在人类。我们研究了产前暴露于全氟辛烷磺酸（PFOS）/全氟辛酸（PFOA）和脐带血糖皮质激素和雄激素水平之间的关系。我们于2002年7月至2005年10月在日本札幌进行了一项以医院为基础的出生队列研究（n = 514）。本研究共纳入185对母婴。采用液相色谱-串联质谱法（LC-MS-MS）测量了孕妇血清样本中的全氟辛烷磺酸和全氟辛酸水平。脐带血中糖皮质激素（皮质醇和可的松）和雄激素[脱氢表雄酮（DHEA）和雄烯二酮]的水平也以同样的方式测量。在调整潜在混杂因素后，我们发现产前PFOS暴露与糖皮质激素水平存在剂量反应关系，而PFOA暴露与糖皮质激素水平无关。皮质醇和可的松浓度为-23.98-ng/mL（95% CI：-0.47.12，-11.99;趋势p = 0.006）和-63.21-ng/mL（95% CI：-132.56，-26.72;与第一个四分位数相比，第四个四分位数产前接触全氟辛烷磺酸的婴儿中，趋势p <0.001）分别较低。与最低四分位数相比，产前全氟辛烷磺酸暴露的最高四分位数与DHEA水平高1.33 ng/mL呈正相关（95% CI：0.17，1.82;趋势p = 0.017），而PFOA与DHEA水平呈负相关。（四分位数4与四分位数1：-1.23 ng/mL，95% CI：-1.72，-0.25;趋势p = 0.004）。我们没有观察到PFCs和雄烯二酮水平之间的显着关联。我们的研究结果表明，产前暴露于全氟化碳是显着相关的糖皮质激素和脱氢表雄酮在脐带血中的水平。[10]张文忠，张文忠. 2017.产前接触全氟化学品与脐带血样本中糖皮质激素和雄激素的关系：北海道研究环境健康展望125：111 - 118; http：//www.example.com
Perfluorinated chemicals (PFCs) disrupt cholesterol homeostasis. All steroid hormones are derived from cholesterol, and steroid hormones such as glucocorticoids and androgenic hormones mediate several vital physiologic functions. However, the in utero effects of PFCs exposure on the homeostasis of these steroid hormones are not well understood in humans. We examined the relationship between prenatal exposure to perfluorooctane sulfonate (PFOS)/perfluorooctanoate (PFOA) and cord blood levels of glucocorticoid and androgenic hormones. We conducted a hospital-based birth cohort study between July 2002 and October 2005 in Sapporo, Japan (n = 514). In total, 185 mother–infant pairs were included in the present study. Prenatal PFOS and PFOA levels in maternal serum samples were measured using liquid chromatography–tandem mass spectrometry (LC-MS-MS). Cord blood levels of glucocorticoid (cortisol and cortisone) and androgenic hormones [dehydroepiandrosterone (DHEA) and androstenedione] were also measured in the same way. We found a dose–response relationship of prenatal PFOS, but not PFOA, exposure with glucocorticoid levels after adjusting for potential confounders. Cortisol and cortisone concentrations were –23.98-ng/mL (95% CI: –0.47.12, –11.99; p for trend = 0.006) and –63.21-ng/mL (95% CI: –132.56, –26.72; p for trend < 0.001) lower, respectively, in infants with prenatal PFOS exposure in the fourth quartile compared with those in the first quartile. The highest quartile of prenatal PFOS exposure was positively associated with a 1.33-ng/mL higher DHEA level compared with the lowest quartile (95% CI: 0.17, 1.82; p for trend = 0.017), whereas PFOA showed a negative association with DHEA levels (quartile 4 vs. quartile 1: –1.23 ng/mL, 95% CI: –1.72, –0.25; p for trend = 0.004). We observed no significant association between PFCs and androstenedione levels. Our results indicate that prenatal exposure to PFCs is significantly associated with glucocorticoid and DHEA levels in cord blood. Goudarzi H, Araki A, Itoh S, Sasaki S, Miyashita C, Mitsui T, Nakazawa H, Nonomura K, Kishi R. 2017. The association of prenatal exposure to perfluorinated chemicals with glucocorticoid and androgenic hormones in cord blood samples: the Hokkaido Study. Environ Health Perspect 125:111–118; http://dx.doi.org/10.1289/EHP142